antibody

HAMSTER ANTI MOUSE CD278

MBS219570

0.25 mg

365 USD

monoclonal

hamsters

nonconjugated

C398.4A

human, rat

immunoprecipitation, flow cytometry, FACS

Antibody

HAMSTER ANTI MOUSE CD278

CD278

inducible T-cell costimulator; Inducible T-cell costimulator; inducible T-cell costimulator; activation-inducible lymphocyte immunomediatory molecule; inducible costimulator; inducible T-cell co-stimulator; Activation-inducible lymphocyte immunomediatory molecule; CD_antigen: CD278

CD278

ICOS; ICOS; AILIM; CD278; CVID1; AILIM

ICOS_HUMAN

Monoclonal

IgG

C398.4A

Hamster

Human, Pig, Rat

199

This item recognises CD278, also known as Inducible T cell costimulator or ICOS, a CD28-superfamily costimulatory molecule. It is expressed on activated T cells and resting memory T cells. It enhances all the basic T cell responses to a foreign antigen, namely proliferation, secretion of lymphokines and up-regulation of molecules that mediate cell-cell interaction. It is essential for the efficient interaction between B and T cells and is involved in antibody responses to T cell dependent antigens. It up-regulates the synthesis of interleukin-10, but not interleukin-2 and prevents the apoptosis of pre-activated T cells. Clone C398.4A has been reported to costimulate T cell activation and proliferation in vitro.

Purified. Purified IgG - liquid

IgG concentration 0.5mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

Immunohistology Frozen, Flow cytometry (FC/FACS), Immunoprecipitation (IP)

Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Flow Cytometry: Minimum Dilution: 1/5; Maximum Dilution: 1/10

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography

Immunogen: Mouse T cell clone D10.G4.1. Buffer Solution: Phosphate buffered saline. Target Species: Mouse

MBS219570 recognises CD278, also known as Inducible T cell costimulator or ICOS, a CD28-superfamily costimulatory molecule. It is expressed on activated T cells and resting memory T cells. It enhances all the basic T cell responses to a foreign antigen, namely proliferation, secretion of lymphokines and up-regulation of molecules that mediate cell-cell interaction. It is essential for the efficient interaction between B and T cells and is involved in antibody responses to T cell dependent antigens. It up-regulates the synthesis of interleukin-10, but not interleukin-2 and prevents the apoptosis of pre-activated T cells. Clone C398.4A has been reported to costimulate T cell activation and proliferation in vitro.

15029518

NP_036224.1

NM_012092.3

19,127 Da

Adaptive Immune System Pathway 366160!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480!!Costimulation By The CD28 Family Pathway 119552!!Immune System Pathway 106386!!Intestinal Immune Network For IgA Production Pathway 128760!!Intestinal Immune Network For IgA Production Pathway 128670!!Primary Immunodeficiency Pathway 83125!!Primary Immunodeficiency Pathway 537!!T Cell Receptor Signaling Pathway 83080

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]

0.25 mg

365 USD