antibody

MOUSE ANTI HUMAN DECTIN-1

MBS219379

0.2 mg

415 USD

monoclonal

mouse

nonconjugated

BD6

flow cytometry, FACS

Antibody

MOUSE ANTI HUMAN DECTIN-1

DECTIN-1

C-type lectin domain family 7 member A isoform b; C-type lectin domain family 7 member A; C-type lectin domain family 7 member A; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin superfamily member 12; DC-associated C-type lectin 1; beta-glucan receptor; dectin-1; dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1; C-type lectin domain family 7, member A; Beta-glucan receptor; C-type lectin superfamily member 12; Dendritic cell-associated C-type lectin 1; DC-associated C-type lectin 1; Dectin-1

DECTIN-1

CLEC7A; CLEC7A; BGR; CANDF4; DECTIN1; CLECSF12; BGR; CLECSF12; DECTIN1; DC-associated C-type lectin 1; Dectin-1

CLC7A_HUMAN

Monoclonal

IgG2b

BD6

Mouse

116

Purified. Purified IgG - liquid

IgG concentration 1.0mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

Flow cytometry (FC/FACS)

Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Flow Cytometry: Minimum Dilution: 1/25; Maximum Dilution: 1/200

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Immunogen: NIH3T3 cells expressing full length Beta-glucan receptor. Fusion Partners: Spleen cells from immunised C57BL/6 were fused with cells of the murine SP2 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Human

Mouse anti Human Dectin-1 antibody, clone BD6 recognizes human Dectin-1, also known as beta-glucan receptor (betaGR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (betaGR-A and betaGR-B) and several minor isoforms. betaGR-A and betaGR-B differs by the presence and absence, respectively, of a stalk region. Mouse anti Human Dectin-1 antibody, clone BD6 recognizes betaGR-A only.

13384604

NP_072092.2

NM_022570.4

Q9BXN2

13,138 Da

Phagosome Pathway 153910!!Phagosome Pathway 153859!!Tuberculosis Pathway 213780!!Tuberculosis Pathway 213743

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

0.2 mg

415 USD