MOUSE ANTI AMPK ALPHA 1/2 | MyBioSource MBS217351 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI AMPK ALPHA 1/2

catalog :

MBS217351

quantity :

0.1 mg

price :

340 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

34.2

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation, enzyme immunoassay

product information

catalog number :

MBS217351

products type :

Antibody

products full name :

MOUSE ANTI AMPK ALPHA 1/2

products short name :

AMPK ALPHA 1/2

other names :

5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; ACACA kinase; AMP -activate kinase alpha 1 subunit; AMP-activated protein kinase, catalytic, alpha-1; AMPK alpha 1; AMPK subunit alpha-1; HMGCR kinase; acetyl-CoA carboxylase kinase; hydroxymethylglutaryl-CoA reductase kinase; tau-protein kinase PRKAA1; protein kinase, AMP-activated, alpha 1 catalytic subunit; Acetyl-CoA carboxylase kinase (EC:2.7.11.27); ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase (EC:2.7.11.31); HMGCR kinase; Tau-protein kinase PRKAA1 (EC:2.7.11.26)

other gene names :

PRKAA1; PRKAA1; AMPK; AMPKa1; AMPK1; AMPK subunit alpha-1; ACACA kinase; HMGCR kinase

uniprot entry name :

AAPK1_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

clone :

34.2

host :

Mouse

sequence length :

559

specificity :

This item recognises both the alpha 1 and the alpha 2 isoforms of AMP-activated protein kinase (AMPK). AMPK is a highly conserved heterotrimeric protein kinase found in all eukaryotes. The heterotrimeric complex exists as multiple isoforms and consists of a catalytic alpha subunit, which is stabilised by non-catalytic regulatory beta- and gamma- subunits. AMPK plays a vital role in maintaining cellular energy homeostasis and is activated by rising levels of AMP under conditions of hypoxia, ischemia, exercise, low glucose levels. AMPK may play an important role in the control of type 2 diabetes and metabolic syndromes. Recent studies suggest that AMPK functions as a suppressor of cell proliferation of both malignant and normal cells.

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Frozen, ELISA (EIA), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB)

app notes :

Western Blot: This item detects a band of approximately 63kDa in rat brain cell lysates. Western Blotting: Minimum Dilution: 1/100; Maximum Dilution: 1/1000

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein G

other info2 :

Immunogen: 29 amino acid peptide within the N-terminal catalytic domain of Drosophila AMPK alpha. Buffer Solution: Phosphate buffered saline. Target Species: Drosophila

products description :

MBS217351 recognises both the alpha 1 and the alpha 2 isoforms of AMP-activated protein kinase (AMPK). AMPK is a highly conserved heterotrimeric protein kinase found in all eukaryotes. The heterotrimeric complex exists as multiple isoforms and consists of a catalytic alpha subunit, which is stabilised by non-catalytic regulatory beta- and gamma- subunits. AMPK plays a vital role in maintaining cellular energy homeostasis and is activated by rising levels of AMP under conditions of hypoxia, ischemia, exercise, low glucose levels. AMPK may play an important role in the control of type 2 diabetes and metabolic syndromes. Recent studies suggest that AMPK functions as a suppressor of cell proliferation of both malignant and normal cells.

ncbi gi num :

94557301

ncbi acc num :

NP_006242.5

ncbi gb acc num :

NM_006251.5

ncbi mol weight :

65,523 Da

ncbi pathways :

AMPK Signaling Pathway 198868!!AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Adipocytokine Signaling Pathway 83093!!Adipocytokine Signaling Pathway 505!!BDNF Signaling Pathway 712093!!Circadian Rhythm Pathway 83084!!Circadian Rhythm Pathway 495!!Energy Metabolism Pathway 198907!!Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway 160972

ncbi summary :

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

size :

0.1 mg

price :

340 USD