RAT ANTI MOUSE CD11b | MyBioSource MBS216534 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RAT ANTI MOUSE CD11b

catalog :

MBS216534

quantity :

0.025 mg

price :

145 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

5C6

reactivity :

mouse

application :

immunocytochemistry, immunoprecipitation, flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS216534

products type :

Antibody

products full name :

RAT ANTI MOUSE CD11b

products short name :

CD11b

other names :

Integrin alpha-M; Integrin alpha-M; integrin alpha-M; CD11 antigen-like family member B; CD11B (p170); CR-3 alpha chain; Mac-1 alpha; cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component receptor 3 alpha-a; complement receptor type 3; leukocyte adhesion receptor MO1; macrophage antigen alpha; integrin alpha M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; CD_antigen: CD11b

products gene name :

CD11b

other gene names :

Itgam; Itgam; CR3; CR3A; MAC1; Cd11b; Ly-40; Mac-1; Mac-1a; CD11b/CD18; F730045J24Rik

uniprot entry name :

ITAM_MOUSE

clonality :

Monoclonal

isotype :

IgG2b

clone :

5C6

host :

Rat

sequence length :

1153

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Frozen, Flow cytometry (FC/FACS), Immunofluorescence (IF), Immunoprecipitation (IP)

app notes :

Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Flow Cytometry: Maximum Dilution: 1/100

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by ion exchange chromatography

other info2 :

Buffer Solution: Phosphate buffered saline. Target Species: Mouse

products description :

Rat anti Mouse CD11b antibody, clone 5C6 recognizes CD11b, also known as the integrin alpha M chain. CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. MBS216530 immunoprecipitates a heterodimer of 165 and 95kD. Rat anti Mouse CD11b antibody, clone 5C6 exhibits various functional properties, reportedly inhibiting adhesion in vitro and inflammatory recruitment in vivo. Rat anti Mouse CD11b antibody, clone 5C6 also inhibits delayed hypersensitivity, potentiates bacterial infections and inhibits type 1 diabetes.

ncbi gi num :

124956

ncbi acc num :

P05555.2

uniprot acc num :

P05555

ncbi mol weight :

115,196 Da

ncbi pathways :

Amoebiasis Pathway (167330); Amoebiasis Pathway (167191); Cell Adhesion Molecules (CAMs) Pathway (83266); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Surface Interactions At The Vascular Wall Pathway (1110059); Extracellular Matrix Organization Pathway (1110302); Focal Adhesion Pathway (198353); Hematopoietic Cell Lineage Pathway (83275); Hematopoietic Cell Lineage Pathway (489); Hemostasis Pathway (1110026)

uniprot summary :

ITGAM: a single-pass type I membrane protein of the integrin alpha chain family. Implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. Also known as CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. A receptor for fibrinogen, factor X and ICAM1. Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Predominantly expressed in monocytes and granulocytes. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion. Cellular Component: cell surface; membrane; integral to membrane; integrin complex; nucleus; external side of plasma membrane. Molecular Function: heparin binding; heparan sulfate proteoglycan binding; opsonin binding; protein heterodimerization activity; metal ion binding; glycoprotein binding. Biological Process: integrin-mediated signaling pathway; neutrophil chemotaxis; leukocyte adhesion; cell-cell adhesion; microglia development; cellular extravasation; activated T cell proliferation; cell adhesion; leukocyte migration during inflammatory response

size1 :

0.025 mg

price1 :

145 USD

more info or order :

MyBioSource product webpage