product summary
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company name :
MyBioSource
product type :
antibody
product name :
MOUSE ANTI CLOSTRIDIUM TETANI TETANUS TOXIN
catalog :
MBS216320
quantity :
0.2 mg
price :
440 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
TetH6
application :
western blot, ELISA, enzyme immunoassay
more info or order :
product information
catalog number :
MBS216320
products type :
Antibody
products full name :
MOUSE ANTI CLOSTRIDIUM TETANI TETANUS TOXIN
products short name :
CLOSTRIDIUM TETANI TETANUS TOXIN
other names :
tetanus toxin tetX; Tetanus toxin; TentoxylysinCleaved into the following 2 chains:Tetanus toxin light chain; Tetanus toxin chain L; Tetanus toxin heavy chain; Tetanus toxin chain H
other gene names :
tetX; Tetanus toxin chain L; Tetanus toxin chain H
uniprot entry name :
TETX_CLOTE
clonality :
Monoclonal
isotype :
IgG1
clone :
TetH6
host :
Mouse
sequence length :
1,315
form :
Purified. Purified IgG - liquid
concentration :
IgG concentration 1.0mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
ELISA (EIA), Functional Assays (FN), Western Blot (WB)
other info1 :
Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
other info2 :
Immunogen: Supernatant from Clostridium tetani. Fusion Partners: Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Bacterial
products description :
Mouse anti Clostridium tetani Tetanus Toxin antibody, clone TetH6 recognizes the tetanus toxin, a neurotoxin produced by the vegetative spore of Clostridium tetani. The toxin causes tetanus, a disease that is characterised by prolonged contraction of skeletal muscle. World-wide, approximately 1 million cases of tetanus occurs annually, resulting in approximately 300,000 to 500,000 deaths, mostly in developing countries. The tetanus toxin has a molecular weight of approximately 150kDa and consists of a heavy chain (B-chain, 100kDa) and a light chain (A-chain, 50kDa) that are connected by a disulfide bond. The toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits the release of the neurotransmitters GABA and glycine by synaptobrevin-2. This results in overactivity in the muscle. The binding of the toxin to neurons is irreversible. Mouse anti Clostridium tetani Tetanus Toxin antibody, clone TetH6 has toxin neutralising activity.
ncbi gi num :
28373188
ncbi acc num :
NP_783831.1
ncbi gb acc num :
NC_004565.1
uniprot acc num :
P04958
ncbi mol weight :
150,682 Da
ncbi pathways :
Disease Pathway (530764); Neurotoxicity Of Clostridium Toxins Pathway (105734); Toxicity Of Tetanus Toxin (TeNT) Pathway (1127569); Uptake And Actions Of Bacterial Toxins Pathway (1127565)
size1 :
0.2 mg
price1 :
440 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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