antibody

MOUSE ANTI HUMAN CD138:FITC

MBS216122

0.025 mg

205 USD

monoclonal

mouse

FITC

B-A38

flow cytometry, FACS

Antibody

MOUSE ANTI HUMAN CD138:FITC

CD138

syndecan-1; Syndecan-1; syndecan-1; CD138 antigen; heparan sulfate proteoglycan fibroblast growth factor receptor; syndecan proteoglycan 1; syndecan 1; CD_antigen: CD138

CD138

SDC1; SDC1; SDC; CD138; SYND1; syndecan; SDC; SYND1

SDC1_HUMAN

Monoclonal

IgG1

B-A38

Mouse

310

FITC. Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid

IgG concentration 0.1 mg/ml

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

Flow cytometry (FC/FACS)

Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Flow Cytometry: Maximum Dilution: Neat

Perservative Stabilisers: 0.09% Sodium Azide. 1% Bovine Serum Albumin. Preparation: Purified IgG prepared by ion exchange chromatography

Buffer Solution: Phosphate buffered saline. Target Species: Human

Mouse anti human CD138 antibody, clone B-A38 recognizes human CD138, also known as Syndecan-1 (SDC-1). CD138 is a member of the transmembrane heparan sulfate proteoglycan family (O'Connell et al. 2004, Sanderson et al. 2008). It is composed of a core protein (comprising 3 domains; a short cytoplasmic domain, a transmembrane domain, and a long extracellular domain) and covalently attached heparan sulfate chains (Sanderson et al. 2008).Syndecan-1 is expressed on the surface of plasma cells within the hematopoietic system and on the surface of mature epithelial cells (O'Connell et al. 2004). It acts as an extracellular matrix receptor, involved in many cellular functions, including cell binding, cell signalling and cytoskeletal organization through cell-cell adhesion and cell-matrix adhesion (Sanderson et al. 2008).

55749480

NP_001006947.1

NM_001006946.1

P18827

32,462 Da

A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway 645305!!Arf6 Trafficking Events Pathway 137954!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480!!Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway 645308!!Chylomicron-mediated Lipid Transport Pathway 106157!!Defective B3GAT3 Causes JDSSDHD Pathway 1127588!!Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway 1127592!!Defective B4GALT7 Causes EDS, Progeroid Type Pathway 1127587!!Defective CHST14 Causes EDS, Musculocontractural Type Pathway 1127591

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]

0.025 mg

205 USD