RAT ANTI MOUSE SIGN-R1:Biotin | MyBioSource MBS216051 product information

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product summary

company name :

MyBioSource

product type :

antibody

product name :

RAT ANTI MOUSE SIGN-R1:Biotin

catalog :

MBS216051

quantity :

0.1 mg

price :

255 USD

clonality :

monoclonal

host :

rat

conjugate :

biotin

clone name :

ER-TR9

reactivity :

mouse

application :

flow cytometry, FACS

product information

catalog number :

MBS216051

products type :

Antibody

products full name :

RAT ANTI MOUSE SIGN-R1:Biotin

products short name :

SIGN-R1

other names :

CD209 antigen-like protein A; CD209 antigen-like protein A; CD209 antigen-like protein A; dendritic cell-specific ICAM-3-grabbing non-integrin; CD209a antigen; Dendritic cell-specific ICAM-3-grabbing non-integrin; DC-SIGN; CD_antigen: CD209

products gene name :

SIGN-R1

other gene names :

Cd209a; Cd209a; CIRE; CD209; CDSIGN; Dcsign; SIGNR5; DC-SIGN; SIGN-R1; DC-SIGN1; Cire; DC-SIGN

uniprot entry name :

C209A_MOUSE

clonality :

Monoclonal

isotype :

IgM

clone :

ER-TR9

host :

Rat

sequence length :

238

form :

Biotin. Purified IgM conjugated to Biotin - liquid

concentration :

IgM concentration 0.1 mg/ml

storage stability :

Store at 4 degree C or at -20o if preferred. This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch.

tested application :

Flow cytometry (FC/FACS)

app notes :

Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Flow Cytometry: Minimum Dilution: Neat; Maximum Dilution: 1/5

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide. 1% Bovine Serum Albumin. Preparation: Ig fraction prepared by ammonium sulphate precipitation

other info2 :

Immunogen: Isolated C3H thymic stromal cells. Fusion Partners: Spleen cells from immunised rats were fused with cells of the Mouse P3-X63-Ag8.563 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Mouse

products description :

Rat anti Mouse Sign-R1 antibody, clone ER-TR9 recognizes mouse SIGN-R1, a C-type lectin that has been identified as a murine homologue of the human DC-SIGN related molecule, L-SIGN. Mouse SIGN-R1 is specifically expressed on marginal zone macrophages in the spleen, medullary and subcapsular sinus macrophages in the lymph nodes, and at lower levels on liver sinusoidal endothelial cells. SIGN-R1 has not been detected on murine dendritic cell populations.Like many C-type lectins, SIGN-R1 functions as a pathogen recognition receptor in vivo and plays an important role in defence against pathogens. Antibodies, produced by clone ER-TR9, are reported to block the uptake of neutral polysaccharides by macrophages (Kraal et al. 1989).

ncbi gi num :

18875404

ncbi acc num :

NP_573501.1

ncbi gb acc num :

NM_133238.5

uniprot acc num :

Q91ZX1

ncbi mol weight :

24,055 Da

ncbi pathways :

Measles Pathway (213308); Measles Pathway (213277); Phagosome Pathway (153914); Phagosome Pathway (153859); Tuberculosis Pathway (213781); Tuberculosis Pathway (213743)

uniprot summary :

CD209: Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri- mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA. Homotetramer. Binds to many viral surface glycoproteins such as HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus envelope glycoproteins, cytomegalovirus gB, HCV E2 and dengue virus major envelope protein E. Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes. 13 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Cellular Component: cell surface; membrane; integral to membrane. Molecular Function: mannose binding; metal ion binding; carbohydrate binding; calcium-dependent protein binding. Biological Process: regulation of gene expression; regulation of T cell proliferation; regulation of blood coagulation; endocytosis

size1 :

0.1 mg

price1 :

255 USD