product summary
request information :
company name :
MyBioSource
product type :
antibody
product name :
MOUSE ANTI HUMAN MAdCAM-1:Biotin
catalog :
MBS215921
quantity :
0.025 mg
price :
190 USD
clonality :
monoclonal
host :
mouse
reactivity :
human
application :
ELISA, FACS, flow cytometry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS215921
products type :
Antibody
products full name :
MOUSE ANTI HUMAN MAdCAM-1:Biotin
products short name :
MAdCAM-1
other names :
mucosal addressin cell adhesion molecule 1 isoform a; Mucosal addressin cell adhesion molecule 1; mucosal addressin cell adhesion molecule 1; MAdCAM-1; hMAdCAM-1; mucosal addressin cell adhesion molecule-1; mucosal vascular addressin cell adhesion molecule 1; N/A
products gene name :
MAdCAM-1
other gene names :
MADCAM1; MADCAM1; MACAM1; MAdCAM-1; hMAdCAM-1
uniprot entry name :
MADCA_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
17F5
host :
Mouse
sequence length :
382
form :
Biotin. Purified IgG conjugated to Biotin - liquid
concentration :
IgG concentration 0.1 mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
ELISA (EIA), Flow cytometry (FC/FACS)
app notes :
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. ELISA: Minimum Dilution: 1ug/ml; Maximum Dilution: 10ug/ml. Flow Cytometry: Minimum Dilution: Neat; Maximum Dilution: 1/10
other info1 :
Perservative Stabilisers: 0.09% Sodium Azide. 1% Bovine Serum Albumin. Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
other info2 :
Immunogen: Recombinant soluble MAdCAM-1-fc fusion protein. Fusion Partners: Spleen cells from immunised Balb/c mice were fused with cells of the mouse P3X63Ag8.653 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Human
products description :
Mouse anti Human MAdCAM-1 antibody, clone 17F5 recognizes human mucosal addressin cell adhesion molecule 1 (MAdCAM-1) a 60kD transmembrane protein that belongs to the immunoglobulin superfamily. MAdCAM-1 is strongly expressed on mucosal lymphoid tissue and high endothelial venules of Peyer's patches. Human MAdCAM-1 interacts with the beta 7 integrin LPAM-1 (alpha4beta7), CD62L, and VLA-4 (alpha4beta1) and is involved in lymphocyte trafficking, Clone 17F5 recognizes the mucin domain of MAdCAM-1. This antibody does not block the function of MAdCAM-1 (Leung, E. et al. 2004).
ncbi gi num :
109633022
ncbi acc num :
NP_570116.2
ncbi gb acc num :
NM_130760.2
uniprot acc num :
Q13477
ncbi mol weight :
21,247 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480!!Extracellular Matrix Organization Pathway 576262!!Immune System Pathway 106386!!Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway 106413!!Integrin Cell Surface Interactions Pathway 106110!!Intestinal Immune Network For IgA Production Pathway 128760!!Intestinal Immune Network For IgA Production Pathway 128670!!Paxillin-independent Events Mediated By A4b1 And A4b7 Pathway 137971
ncbi summary :
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
size :
0.025 mg
price :
190 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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