MOUSE ANTI HUMAN AMH | MyBioSource MBS215704 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI HUMAN AMH

catalog :

MBS215704

quantity :

1 mL

price :

625 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6-May

reactivity :

human, mouse

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS215704

products type :

Antibody

products full name :

MOUSE ANTI HUMAN AMH

products short name :

AMH

other names :

muellerian-inhibiting factor; Muellerian-inhibiting factor; muellerian-inhibiting factor; Mullerian inhibiting factor; Mullerian inhibiting substance; anti-Muellerian hormone; muellerian-inhibiting substance; anti-Mullerian hormone; Anti-Muellerian hormone; AMH; Muellerian-inhibiting substance; MIS

products gene name :

AMH

other gene names :

AMH; AMH; MIF; MIS; MIF; AMH; MIS

uniprot entry name :

MIS_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

6-May

host :

Mouse

reactivity :

Baboon, Mouse, Sheep, Squirrel monkey

sequence length :

560

form :

Concentrated Tissue Culture Supernatant - liquid

storage stability :

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch

tested application :

Immunohistology Paraffin*, Western Blot (WB)

app notes :

Immunohistology - Paraffin: Minimum Dilution: 1/20; Maximum Dilution: 1/40; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.

other info1 :

Perservative Stabilisers: 0.1% Sodium Azide

other info2 :

Histology Positive Control Tissue: Ovary. Target Species: Human

products description :

Mouse anti Human AMH, clone 5/6 recognizes human anti-mullerian hormone (AMH), originally classified as a foetal testicular hormone that inhibits Mullerian duct development. AMH is expressed post-natally by immature Sertoli cells, and to a lesser degree by granulosa cells. AMH plays a role in testicular differentiation and in the regulation of ovarian follicle growth. AMH is a member of the TGF beta superfamily. It is secreted as a homodimeric 140kDa disulphide linked precursor that is cleaved to release the mature 30kDa homodimer.

ncbi gi num :

157266298

ncbi acc num :

NP_000470.2

ncbi gb acc num :

NM_000479.3

uniprot acc num :

P03971

ncbi mol weight :

59,195 Da

ncbi pathways :

ALK2 Signaling Events Pathway (137983); BMP Signaling Pathway (1084755); BMP Signaling Pathway (1108218); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); TGF-beta Signaling Pathway (83064); TGF-beta Signaling Pathway (475); CAMP Signaling Pathway (1017634)

ncbi summary :

Anti-Mullerian hormone is a member of the transforming growth factor-beta gene family which mediates male sexual differentiation. Anti-Mullerian hormone causes the regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes. Some mutations in the anti-Mullerian hormone result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2008]

uniprot summary :

AMH: This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin. Defects in AMH are the cause of persistent Muellerian duct syndrome type 1 (PMDS1). PMDS1 is a form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males. Belongs to the TGF-beta family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: extracellular space; cytoplasm; extracellular region. Molecular Function: growth factor activity; hormone activity; transforming growth factor beta receptor binding; receptor binding. Biological Process: sex determination; response to drug; Mullerian duct regression; cell-cell signaling; gonadal mesoderm development; preantral ovarian follicle growth; sex differentiation; response to organic cyclic substance; urogenital system development; aging; activation of NF-kappaB transcription factor. Disease: Persistent Mullerian Duct Syndrome, Types I And Ii

size1 :

1 mL

price1 :

625 USD

more info or order :

MyBioSource product webpage