MOUSE ANTI CYCLIN D1 | MyBioSource MBS215186 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI CYCLIN D1

catalog :

MBS215186

quantity :

0.01 mg

price :

215 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CD1.1

reactivity :

human

application :

flow cytometry, FACS

product information

catalog number :

MBS215186

products type :

Antibody

products full name :

MOUSE ANTI CYCLIN D1

products short name :

CYCLIN D1

other names :

G1/S-specific cyclin-D1; G1/S-specific cyclin-D1; G1/S-specific cyclin-D1; B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL-1 oncogene; PRAD1 oncogene; cyclin D1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene

products gene name :

CYCLIN D1

other gene names :

CCND1; CCND1; BCL1; PRAD1; U21B31; D11S287E; BCL1; PRAD1; BCL-1

uniprot entry name :

CCND1_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

CD1.1

host :

Mouse

sequence length :

295

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Frozen, Flow cytometry (FC/FACS)*, Immunohistology Paraffin*

app notes :

Flow Cytometry: Application Note: Membrane permeabilization is required for this application. MyBioSource recommend the use of Leucoperm . Immunohistology - Paraffin: Minimum Dilution: 1/10; Maximum Dilution: 1/100; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant

other info2 :

Histology Positive Control Tissue: Small intestine, colon. Buffer Solution: TRIS buffered glycine. Target Species: Human

products description :

Mouse anti Cyclin D1 antibody, clone CD1.1 recognizes cyclin D1, a 295 amino acid, 36kDa nuclear protein which belongs to the highly conserved cyclin family. D type cyclins are predominantly expressed in the G1 phase of the cell cycle. Cyclin D1 study is of interest in various forms of malignancy and over expression has been linked to poor prognosis (Bartkova et al. 1995).

ncbi gi num :

16950655

ncbi acc num :

NP_444284.1

ncbi gb acc num :

NM_053056.2

uniprot acc num :

P24385

ncbi mol weight :

33,729 Da

ncbi pathways :

AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); ATF-2 Transcription Factor Network Pathway (138006); Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Androgen Receptor Signaling Pathway (198806); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); C-MYB Transcription Factor Network Pathway (138073); Cell Cycle Pathway (530733)

ncbi summary :

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]

uniprot summary :

CCND1: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Protein type: Activator; Cell cycle regulation; Oncoprotein; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 11q13. Cellular Component: nucleoplasm; tight junction; transcriptional repressor complex; membrane; cyclin-dependent protein kinase holoenzyme complex; intracellular; nucleus; cytosol. Molecular Function: protein binding; enzyme binding; histone deacetylase binding; protein complex binding; cyclin-dependent protein kinase regulator activity; protein kinase binding; transcription factor binding; transcription corepressor activity; protein kinase activity. Biological Process: G1 DNA damage checkpoint; lactation; fat cell differentiation; establishment and/or maintenance of chromatin architecture; negative regulation of Wnt receptor signaling pathway; positive regulation of cyclin-dependent protein kinase activity; re-entry into mitotic cell cycle; positive regulation of mammary gland epithelial cell proliferation; negative regulation of epithelial cell differentiation; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; response to magnesium ion; response to vitamin E; Leydig cell differentiation; response to iron ion; response to corticosterone stimulus; response to X-ray; response to drug; organ regeneration; Notch signaling pathway; transcription, DNA-dependent; unfolded protein response; mammary gland epithelial cell proliferation; response to organic nitrogen; liver development; response to ethanol; response to estrogen stimulus; cell division; positive regulation of protein amino acid phosphorylation; mitotic cell cycle; response to calcium ion; response to DNA damage stimulus; G1/S transition of mitotic cell cycle. Disease: Von Hippel-lindau Syndrome; Myeloma, Multiple

size1 :

0.01 mg

price1 :

215 USD