RAT ANTI MOUSE CD204 | MyBioSource MBS214942 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RAT ANTI MOUSE CD204

catalog :

MBS214942

quantity :

0.025 mg

price :

145 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

2F8

reactivity :

mouse

application :

western blot, ELISA, immunoprecipitation, flow cytometry, FACS, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS214942

products type :

Antibody

products full name :

RAT ANTI MOUSE CD204

products short name :

CD204

other names :

macrophage scavenger receptor types I and II isoform b; Macrophage scavenger receptor types I and II; macrophage scavenger receptor types I and II; SR-A; macrophage acetylated LDL receptor I and II; scavenger receptor type A; macrophage scavenger receptor 1; Macrophage acetylated LDL receptor I and II; Scavenger receptor type A; SR-A; CD_antigen: CD204

products gene name :

CD204

other gene names :

Msr1; Msr1; MSR; Scvr; MRS-A; MSR-A; SR-AI; SR-AII; Scara1; Scvr; SR-A

uniprot entry name :

MSRE_MOUSE

clonality :

Monoclonal

isotype :

IgG2b

clone :

2F8

host :

Rat

sequence length :

458

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Frozen*, ELISA (EIA), Flow cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB)*

app notes :

Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Immunohistology - Frozen: Application Note: The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. MyBioSource recommends the use of acetone fixation for frozen sections. . Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/100. Western Blotting: Application Note: This product recognises CD204 in J774 cells under non-reduced conditions only.

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

other info2 :

Immunogen: Raw 264 cell line. Fusion Partners: Spleen cells from immunised AO rats were fused with cells of the Y3 rat myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Mouse

ncbi gi num :

164664520

ncbi acc num :

NP_001106797.1

ncbi gb acc num :

NM_001113326.1

ncbi mol weight :

38,773 Da

ncbi pathways :

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (1110598); Phagosome Pathway (153914); Phagosome Pathway (153859); Scavenging By Class A Receptors Pathway (1110600)

uniprot summary :

MSR1: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL. Defects in MSR1 may be a cause of prostate cancer (PC). A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet- ring cell carcinoma and neuroendocrine carcinoma. MSR1 variants may play a role in susceptibility to prostate cancer. MSR1 variants have been found in individuals with prostate cancer and co-segregate with the disease in some families. Defects in MSR1 may be a cause of Barrett esophagus (BE). A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Genetic variants in MSR1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Cellular Component: collagen; membrane; integral to membrane; plasma membrane; cytoplasmic vesicle; cytosol. Molecular Function: low-density lipoprotein binding; scavenger receptor activity. Biological Process: receptor-mediated endocytosis; cholesterol transport; lipoprotein transport; endocytosis

size1 :

0.025 mg

price1 :

145 USD

more info or order :

MyBioSource product webpage