MOUSE ANTI HUMAN ACTH | MyBioSource MBS214624 product information

product summary

request information :

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI HUMAN ACTH

catalog :

MBS214624

quantity :

1 mg

price :

390 USD

clonality :

monoclonal

host :

mouse

reactivity :

human

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS214624

products type :

Antibody

products full name :

MOUSE ANTI HUMAN ACTH

products short name :

ACTH

other names :

pro-opiomelanocortin preproprotein; Pro-opiomelanocortin; pro-opiomelanocortin; adrenocorticotropic hormone; adrenocorticotropin; alpha-MSH; alpha-melanocyte-stimulating hormone; beta-LPH; beta-MSH; beta-endorphin; beta-melanocyte-stimulating hormone; corticotropin-like intermediary peptide; corticotropin-lipotropin; gamma-LPH; gamma-MSH; lipotropin beta; lipotropin gamma; melanotropin alpha; melanotropin beta; melanotropin gamma; met-enkephalin; opiomelanocortin prepropeptide; pro-ACTH-endorphin; proopiomelanocortin preproprotein; proopiomelanocortin; Corticotropin-lipotropinCleaved into the following 11 chains:NPP; Melanotropin gammaAlternative name(s):Gamma-MSH

products gene name :

ACTH

other gene names :

POMC; POMC; LPH; MSH; NPP; POC; ACTH; CLIP; POMC; ACTH; CLIP

uniprot entry name :

COLI_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

57 (BGN/1388/66)

host :

Mouse

sequence length :

267

sequence :

SYSMEHFRWGKPVGKKRRPVKVYP

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

ELISA (EIA), Immunohistology Paraffin*

app notes :

Immunohistology - Paraffin: Minimum Dilution: 1/100; Maximum Dilution: 1/200; Application Note: This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase.

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein A

other info2 :

Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

Mouse anti Human ACTH antibody (Clone 57, BGN/1388/66) recognizes 1-24 ACTH (Synacthen) which, as a synthetic analogue of naturally-occurring Adrenocorticotropic Hormone, can be used to measure adrenal reserve and for the diagnosis of adrenal insufficiency by acute adrenocortical stimulation. ACTH, released from the anterior pituitary gland in response to corticotropin-releasing hormone from the hypothalamus, acts on the adrenal cortex to stimulate the production of corticosteroids such as cortisol, involved in the response to stress. Studies have shown that the administration of 1-24 ACTH increases blood pressure, believed to be attributed to an increase in ACTH-stimulated cortisol secretion, in association with increased cardiac output. Mouse anti Human ACTH antibody does not recognize 17-39 ACTH (CLIP). It does cross-reacts with rat N-terminal ACTH.

ncbi gi num :

4505949

ncbi acc num :

NP_000930.1

ncbi gb acc num :

NM_000939.2

uniprot acc num :

P01189

ncbi mol weight :

29,424 Da

ncbi pathways :

Adipocytokine Signaling Pathway 83093!!Adipocytokine Signaling Pathway 505!!Androgen Biosynthesis Pathway 106154!!Biological Oxidations Pathway 105698!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Corticotropin-releasing Hormone Pathway 920957!!Cytochrome P450 - Arranged By Substrate Type Pathway 105700!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664!!Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway 1127640!!Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway 1127641

ncbi summary :

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Nov 2014]

size :

1 mg

price :

390 USD

more info or order :

MyBioSource product webpage