This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
MOUSE ANTI ANTHRAX PROTECTIVE ANTIGEN
catalog :
MBS214545
quantity :
0.2 mg
price :
440 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
C3
reactivity :
anthrax
application :
western blot, ELISA, enzyme immunoassay
product information
catalog number :
MBS214545
products type :
Antibody
products full name :
MOUSE ANTI ANTHRAX PROTECTIVE ANTIGEN
products short name :
ANTHRAX
other names :
pXO1-110; Protective antigen; pXO1-110; Anthrax toxins translocating protein; PA-83; PA83
other gene names :
pxo1_110; pagA; pag; PA; PA83; PA20; PA63
uniprot entry name :
PAG_BACAN
clonality :
Monoclonal
isotype :
IgG1
clone :
C3
host :
Mouse
sequence length :
764
form :
Purified. Purified IgG - liquid
concentration :
IgG concentration 1.0mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
ELISA (EIA), Western Blot (WB)
other info1 :
Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
other info2 :
Immunogen: Highly purified protective antigen of Bacillus anthracis. Fusion Partners: Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Bacterial
products description :
Mouse anti Anthrax Protective Antigen antibody, clone C3 recognizes the Protective Antigen of the anthrax toxin. Bacillus anthracis produces a toxin composed of three proteins, the Protective Antigen (PA), the Edema Factor (EF) and the Lethal Factor (LF). The three proteins depend on each other for their toxic effect. Both EF and LF functions intracellularly but are too large to enter the cell through existing channels. The PA is responsible for transporting the EF and LF into cells. The 83kDa PA (PA83) binds to the cell surface where a 20 kDa N-terminal fragment (PA20) is cleaved off, exposing binding sites for LF and EF. The remaining 63 kDa portion (PA63) oligomerizes to form a heptamer pre-pore, which then associates with up to three molecules of EF and/or LF. The receptor complex is internalized within endocytotic vessels that are subsequently acidified, transforming the PA heptamer into a pore that releases the active enzymes EF (an adenylate cyclase) and LF (a protease targeting MAPKKs) into the cytosol. Mouse anti Anthrax Protective Antigen antibody, clone C3 does not cross-react with the Lethal Factor of Bacillus anthracis, Yersinia pestis, Francisella tularensis or Toxoplasma gondii. The antibody recognizes both the 83kDa and 63kDa truncated form of PA.
ncbi gi num :
10956357
ncbi acc num :
NP_052806.1
ncbi gb acc num :
NC_001496.1
uniprot acc num :
P13423
ncbi mol weight :
85,811 Da
ncbi pathways :
Cellular Roles Of Anthrax Toxin Pathway 138076!!Disease Pathway 530764!!Uptake And Actions Of Bacterial Toxins Pathway 1127565!!Uptake And Function Of Anthrax Toxins Pathway 1127574
size :
0.2 mg
price :
440 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

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