antibody

MOUSE ANTI HUMAN FIBRINOPEPTIDE A

MBS214503

0.2 mg

400 USD

monoclonal

mouse

nonconjugated

49D2

ELISA, enzyme immunoassay

Antibody

MOUSE ANTI HUMAN FIBRINOPEPTIDE A

FIBRINOPEPTIDE A

fibrinogen alpha chain isoform alpha-E preproprotein; Fibrinogen alpha chain; fibrinogen alpha chain; fibrinogen, A alpha polypeptide; fibrinogen alpha chain

FGA; FGA; Fib2

FIBA_HUMAN

Monoclonal

IgG2a

49D2

Mouse

866

Purified. Purified IgG - liquid

IgG concentration 1.0mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

ELISA (EIA)

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant

Immunogen: Synthetic fibrinopeptide A conjugated to a carrier protein. Fusion Partners: Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Human

Mouse anti Human Fibrinopeptide A antibody, clone 49D2 recognizes human fibrinopeptide A, a 16aa sequence found on the alpha chain of fibrinogen. The fibrinopeptides (A and B, from the alpha and beta chains of fibrinogen, respectively) serves to prevent fibrinogen from polymerising with itself. Following vascular injury, thrombin cleaves through the fibrinopeptides, which exposes the N terminal polymerisation sites, to allow formation of a blood clot. Mouse anti Human Fibrinopeptide A antibody, clone 49D2 recognizes the fibrinopeptide region in the alpha-chain of fibrinogen (amino acids 20-35) and free fibrinopeptide A.

4503689

NP_000499.1

NM_000508.3

P02671

69,757 Da

Amyloids Pathway 366238!!Blood Clotting Cascade Pathway 198840!!Common Pathway 106060!!Complement And Coagulation Cascades Pathway 83073!!Complement And Coagulation Cascades Pathway 484!!Disease Pathway 530764!!Extracellular Matrix Organization Pathway 576262!!Formation Of Fibrin Clot (Clotting Cascade) Pathway 106057!!GRB2:SOS Provides Linkage To MAPK Signaling For Integrins Pathway 106055!!Hemostasis Pathway 106028

The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq, Jul 2008]

0.2 mg

400 USD