MOUSE ANTI HUMAN CD44 | MyBioSource MBS214487 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI HUMAN CD44

catalog :

MBS214487

quantity :

0.2 mg

price :

430 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

156-3C11

reactivity :

human

application :

western blot, immunoprecipitation, flow cytometry, FACS

product information

catalog number :

MBS214487

products type :

Antibody

products full name :

MOUSE ANTI HUMAN CD44

products short name :

CD44

other names :

CD44 antigen isoform 1; CD44 antigen; CD44 antigen; GP90 lymphocyte homing/adhesion receptor; Hermes antigen; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; epican; extracellular matrix receptor III; hematopoietic cell E- and L-selectin ligand; heparan sulfate proteoglycan; homing function and Indian blood group system; hyaluronate receptor; phagocytic glycoprotein 1; CD44 molecule (Indian blood group); CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD_antigen: CD44

products gene name :

CD44

other gene names :

CD44; CD44; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; LHR; MDU2; MDU3; MIC4; ECMR-III; PGP-1; PGP-I

uniprot entry name :

CD44_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

clone :

156-3C11

host :

Mouse

reactivity :

African green monkey, Baboon

sequence length :

742

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Frozen, Flow cytometry (FC/FACS), Immunoprecipitation (IP), Immunohistology Paraffin*, Western Blot (WB)

app notes :

Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Western Blot: This item detects a band of approximately 80kDa in HeLa cell lysates. Immunohistology - Frozen: Maximum Dilution: 1/100. Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/100. Immunohistology - Paraffin: Maximum Dilution: 1/100; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein A

other info2 :

Histology Positive Control Tissue: Human tonsil. Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

Mouse anti Human CD44 antibody, clone 156-3C11 recognizes human Phagocytic glycoprotein 1 also known as CD44, a 90kD single pass type I transmembrane glycoproteinprotein which is otherwise known as HCAM or CD44s. Various isoforms of CD44 exist due to differential expression of exon products form the membrane proximal region of the extracellular domain. Clone 156-3C11 recognizes the 90kD standard form lacking any of the alternative spliced products, the clone is expected to recognize all isoforms of CD44. CD44 is expressed on leucocytes, erythrocytes, white matter of the brain and some epithelial cells of the breast and small intestine. Antibodies produced by clone 156-3C11 recognise epitope 3, defined as a protease resistant epitope on the CD44 molecule (CD44 and CD45R Cluster report. In Leucocyte Typing V. White cell differentiation antigens. Eds Schlossman, S.F. et al). CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration (Lesley et al. 1990). CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing (Shimizu et al. 1989). CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential (East and Hart 1993).

ncbi gi num :

48255935

ncbi acc num :

NP_000601.3

ncbi gb acc num :

NM_000610.3

uniprot acc num :

P16070

ncbi mol weight :

15,635 Da

ncbi pathways :

Cell Surface Interactions At The Vascular Wall Pathway 106062!!Cytokine Signaling In Immune System Pathway 366171!!Defective B3GAT3 Causes JDSSDHD Pathway 1127588!!Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway 1127592!!Defective B4GALT7 Causes EDS, Progeroid Type Pathway 1127587!!Defective CHST14 Causes EDS, Musculocontractural Type Pathway 1127591!!Defective CHST3 Causes SEDCJD Pathway 1127590!!Defective CHST6 Causes MCDC1 Pathway 1127593!!Defective CHSY1 Causes TPBS Pathway 1127589!!Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway 1127594

ncbi summary :

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

size :

0.2 mg

price :

430 USD