MOUSE ANTI HUMAN ANNEXIN V:Biotin | MyBioSource MBS214473 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI HUMAN ANNEXIN V:Biotin

catalog :

MBS214473

quantity :

100 Tests

price :

575 USD

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

VAA-33

reactivity :

human

application :

flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS214473

products type :

Antibody

products full name :

MOUSE ANTI HUMAN ANNEXIN V:Biotin

products short name :

ANNEXIN V

other names :

annexin A5; Annexin A5; annexin A5; CBP-I; PAP-I; VAC-alpha; anchorin CII; annexin V; annexin-5; calphobindin I; endonexin II; epididymis secretory protein Li 7; lipocortin V; placental anticoagulant protein 4; placental anticoagulant protein I; thromboplastin inhibitor; vascular anticoagulant-alpha; annexin A5; Anchorin CII; Annexin V; Annexin-5; Calphobindin I; CBP-I; Endonexin II; Lipocortin V; Placental anticoagulant protein 4; PP4; Placental anticoagulant protein I; PAP-I; Thromboplastin inhibitor; Vascular anticoagulant-alpha; VAC-alpha

other gene names :

ANXA5; ANXA5; PP4; ANX5; ENX2; RPRGL3; HEL-S-7; ANX5; ENX2; PP4; CBP-I; PP4; PAP-I; VAC-alpha

uniprot entry name :

ANXA5_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

clone :

VAA-33

host :

Mouse

sequence length :

320

form :

Biotin. Purified IgG conjugated to Biotin - liquid

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Flow cytometry (FC/FACS)

app notes :

Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.

other info1 :

Perservative Stabilisers: 0.02% Sodium Azide (NaN3). 1% Bovine Serum Albumin . Preparation: Purified IgG prepared by affinity chromatography on Protein G

other info2 :

Immunogen: Recombinant Annexin V. Buffer Solution: TRIS buffered saline. Target Species: Human

products description :

Mouse anti Human Annexin V antibody, clone VAA-33 specifically recognizes human Annexin V, a phospholipid binding protein which binds with high affinity and selectivity to phosphatidylserine (PS), in the presence of calcium. The translocation of PS from the cytosolic leaflet to the outer leaflet of the plasma membrane, due to a loss in plasma membrane asymmetry during apoptosis, acts as an in vivo signal for the removal of the dying cell by phagocytosis. Detection of PS using Annexin V therefore provides a reliable diagnostic tool for the indication of early programmed cell death. Annexin V has also been identified as an anticoagulant protein in the blood coagulation cascade, by acting as an inhibitor of prothrombin activation. The presence of antibodies to Annexin V, are associated with systemic lupus erythematosus (SLE), recurrent spontaneous abortions and systemic sclerosis (SSc). Mouse anti Human Annexin V antibody, clone VAA-33 has been reported to work in Western blotting applications.

ncbi gi num :

4502107

ncbi acc num :

NP_001145.1

ncbi gb acc num :

NM_001154.3

uniprot acc num :

P08758

ncbi mol weight :

35,937 Da

ncbi pathways :

Prostaglandin Synthesis And Regulation Pathway (198912)

ncbi summary :

The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008]

uniprot summary :

ANXA5: a calcium/phospholipid-binding protein and an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. The binding of labeled ANXA5 to phosphatidylserine is used as a marker of apoptosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion. Protein type: Calcium-binding; Inhibitor; Lipid-binding; Apoptosis. Chromosomal Location of Human Ortholog: 4q27. Cellular Component: focal adhesion; membrane; cytoplasm; intracellular; external side of plasma membrane. Molecular Function: phospholipase inhibitor activity; calcium-dependent phospholipid binding; phospholipid binding; calcium ion binding. Biological Process: response to organic substance; negative regulation of catalytic activity; blood coagulation; negative regulation of coagulation; signal transduction; negative regulation of apoptosis. Disease: Pregnancy Loss, Recurrent, Susceptibility To, 3

size1 :

100 Tests

price1 :

575 USD

more info or order :

MyBioSource product webpage