antibody

MOUSE ANTI HUMAN B7-H4

MBS214417

0.1 mg

265 USD

monoclonal

mouse

nonconjugated

MIH43

flow cytometry, FACS

Antibody

MOUSE ANTI HUMAN B7-H4

B7-H4

V-set domain-containing T-cell activation inhibitor 1 isoform 2; V-set domain-containing T-cell activation inhibitor 1; V-set domain-containing T-cell activation inhibitor 1; B7 family member, H4; B7 homolog 4; B7 superfamily member 1; T cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; VTCN1; immune costimulatory protein B7-H4; V-set domain containing T cell activation inhibitor 1; B7 homolog 4; B7-H4; B7h.5; Immune costimulatory protein B7-H4; Protein B7S1; T-cell costimulatory molecule B7x

B7-H4

VTCN1; VTCN1; B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291; B7-H4

VTCN1_HUMAN

Monoclonal

IgG1

MIH43

Mouse

187

Purified. Purified IgG - liquid

IgG concentration 1.0mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

Immunohistology Frozen, Flow cytometry (FC/FACS), Immunohistology Paraffin

Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Immunohistology: This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Flow Cytometry: Minimum Dilution: 1/25; Maximum Dilution: 1/50. Immunohistology - Paraffin: Maximum Dilution: 1/50

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Immunogen: Human B7-H4. Histology Positive Control Tissue: Tonsil, breast carcinoma. Buffer Solution: Phosphate buffered saline. Target Species: Human

Mouse anti Human B7-H4 antibody, clone MIH43 recognizes human B7-H4, also known as B7x, a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response. B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7-H4 could be a useful prognostic marker in Renal Cell Carcinoma (RCC).

359718944

NP_001240778.1

NM_001253849.1

Q7Z7D3

20,743 Da

Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

0.1 mg

265 USD