antibody

MOUSE ANTI HUMAN C1q

MBS214405

0.1 ml

500 USD

monoclonal

mouse

nonconjugated

3R9/2

western blot, ELISA, immunocytochemistry, flow cytometry, FACS, enzyme immunoassay

Antibody

MOUSE ANTI HUMAN C1q

C1q

complement C1q subcomponent subunit A; Complement C1q subcomponent subunit A; complement C1q subcomponent subunit A; complement component 1, q subcomponent, alpha polypeptide; complement component C1q, A chain; complement component 1, q subcomponent, A chain

C1q

C1QA; C1QA

C1QA_HUMAN

Monoclonal

IgG1

3R9/2

Mouse

245

Purified. Purified IgG - liquid

Approximate Protein Concentration: 1.0 mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from the date of despatch.

Immunohistology Frozen, ELISA (EIA), Flow cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)

Immunohistology: For best results MyBioSource recommend HISTAR detection kits. Immunohistology - Frozen: Minimum Dilution: 1:500; Maximum Dilution: 1:1000

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein A

Histology Positive Control Tissue: Kidney from patients with streptococcal glomerulonephritis. Buffer Solution: Borate buffered saline. Target Species: Human

Mouse anti human C1q antibody, clone 3R9/2, recognizes human complement component 1 q (C1q), a 156kDa secreted protein. C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system. C1q is composed of six A-, six B-chains and six C-polypeptide chains. Each chain contains a collagen-like region located near the N-terminus and a C-terminal globular region. These regions bind the Fc region of IgM and IgG molecules, initiating the classical pathway of complement activation. C1q deficiency has been associated with lupus erythematosus and glomerulonephritis (Troedson et al. 2013).

7705753

NP_057075.1

NM_015991.2

26,017 Da

Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Classical Antibody-mediated Complement Activation Pathway 106409!!Complement Activation, Classical Pathway 198823!!Complement And Coagulation Cascades Pathway 198880!!Complement And Coagulation Cascades Pathway 83073!!Complement And Coagulation Cascades Pathway 484!!Complement Cascade Pathway 106405!!Creation Of C4 And C2 Activators Pathway 106407!!Immune System Pathway 106386

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008]

0.1 ml

500 USD