MOUSE ANTI HUMAN CD206 | MyBioSource MBS214362 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI HUMAN CD206

catalog :

MBS214362

quantity :

0.1 mg

price :

260 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7-450

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - frozen section

product information

catalog number :

MBS214362

products type :

Antibody

products full name :

MOUSE ANTI HUMAN CD206

products short name :

CD206

other names :

macrophage mannose receptor 1; Macrophage mannose receptor 1; macrophage mannose receptor 1; C-type lectin domain family 13 member D; macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1-like 1; mannose receptor, C type 1; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1; CD_antigen: CD206

products gene name :

CD206

other gene names :

MRC1; MRC1; MMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1; CLEC13D; CLEC13DL; MRC1L1; MMR

uniprot entry name :

MRC1_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

clone :

7-450

host :

Mouse

sequence length :

1456

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Frozen

app notes :

Immunohistology - Frozen: Minimum Dilution: 1/50; Maximum Dilution: 1/500

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

other info2 :

Immunogen: Monocyte-derived dendritic cells. Histology Positive Control Tissue: Human tonsil. Fusion Partners: Spleen cells from immunised Balb/c mice were fused with cells of the X63-Ag8.653 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

Mouse anti Human CD206 antibody, clone 7-450 recognizes human CD206, otherwise known as macrophage mannose receptor (MMR), a transmembrane protein and member of the multilectin family of pattern recognition receptors (PRRs), which mediates phagocytosis and endocytosis, and is modulated by a range of factors including cytokines, immunoglobulin receptors and pathogens. CD206 has two extracellular lectin binding sites: the cysteine-rich domain binds to sulphated sugars of glycoproteins such as thyroid stimulating hormone, whilst the recognition of mannose and fucose occurs through carbohydrate recognition domains (CRDs). The widespread distribution and recognition of a wide range of antigens by macrophages, plays a key role in both innate and adaptive immunity, with CD206 able to bind to both gram-negative and gram-positive bacteria, mycobacterium, yeasts, fungi and parasites. The expression of CD206 is not restricted to macrophages, but is also present on immature dendritic cells (DCs), endothelial cells, kidney mesangial cells, retinal pigment epithelium and tracheal smooth muscle cells.

ncbi gi num :

4505245

ncbi acc num :

NP_002429.1

ncbi gb acc num :

NM_002438.3

uniprot acc num :

P22897

ncbi mol weight :

56,554 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Antigen Processing-Cross Presentation Pathway (477122); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Cross-presentation Of Soluble Exogenous Antigens (endosomes) Pathway (477126); Immune System Pathway (106386); Phagosome Pathway (153910); Phagosome Pathway (153859); Tuberculosis Pathway (213780); Tuberculosis Pathway (213743)

ncbi summary :

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Apr 2011]

uniprot summary :

MRC1: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 10p12.33. Cellular Component: cell surface; integral to plasma membrane; plasma membrane; endosome membrane. Molecular Function: mannose binding; protein binding; transmembrane receptor activity; receptor activity. Biological Process: receptor-mediated endocytosis; signal transduction

size1 :

0.1 mg

price1 :

260 USD