This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
RAT ANTI MOUSE CD51
catalog :
MBS214310
quantity :
0.25 mg
price :
355 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
RMV-7
reactivity :
mouse
application :
immunoprecipitation, flow cytometry, FACS
product information
catalog number :
MBS214310
products type :
Antibody
products full name :
RAT ANTI MOUSE CD51
products short name :
CD51
other names :
integrin alpha-V; Integrin alpha-V; integrin alpha-V; vitronectin receptor alpha polypeptide (VNRA); vitronectin receptor subunit alpha; integrin alpha V; Vitronectin receptor subunit alpha; CD_antigen: CD51Cleaved into the following 2 chains:Integrin alpha-V heavy chain; Integrin alpha-V light chain
products gene name :
CD51
other gene names :
Itgav; Itgav; CD51; 1110004F14Rik; 2610028E01Rik; D430040G12Rik
uniprot entry name :
ITAV_MOUSE
clonality :
Monoclonal
isotype :
IgG1
clone :
RMV-7
host :
Rat
sequence length :
1044
form :
Purified. Purified IgG - liquid
concentration :
IgG concentration 1.0mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Immunohistology Frozen, Flow cytometry (FC/FACS), Immunoprecipitation (IP)
app notes :
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Immunohistology - Frozen: Minimum Dilution: 1/25; Maximum Dilution: 1/100. Flow Cytometry: Minimum Dilution: 1/25; Maximum Dilution: 1/100
other info1 :
Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
other info2 :
Immunogen: Cultured LAK cells from Balb/c mice. Fusion Partners: Spleen cells from immunised SD rats were fused with the cells of the P3X.63Ag8.653 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Mouse
products description :
Rat anti Mouse CD51 antibody, clone RMV-7 recognizes murine CD51, a 140 kD alpha subunit of the vitronectin receptor, which is otherwise known as the integrin alpha v chain. CD51 can form heterodimers at the cell surface with a variety of beta integrins including CD29 and CD61. Heterodimers of CD51/CD61 function as a receptor for vitronectin, and a wide array of RGD-containing proteins including fibronectin, fibrinogen, von Willebrand factor, laminin, thrombospondin and osteopontin. CD51/CD61 is primarily expressed on myeloid cells and activated T-cells. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity (Takahashi et al. 1990).
ncbi gi num :
154240716
ncbi acc num :
NP_032428.2
ncbi gb acc num :
NM_008402.3
uniprot acc num :
P43406
ncbi mol weight :
115,360 Da
ncbi pathways :
Adaptive Immune System Pathway 1110669!!Antigen Processing-Cross Presentation Pathway 1110689!!Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 117303!!Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 116129!!Axon Guidance Pathway 1111058!!Cell Adhesion Molecules (CAMs) Pathway 83266!!Cell Adhesion Molecules (CAMs) Pathway 480!!Class I MHC Mediated Antigen Processing Presentation Pathway 1110686!!Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway 1110690!!Developmental Biology Pathway 1111057
ncbi summary :
This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 1, beta 3, beta 6 and beta 8. The heterodimer of alpha v and beta 3 forms the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. In mouse, deficiency of this gene is associated with defects in vascular morphogenesis in the brain and early post-natal death. [provided by RefSeq, May 2013]
size :
0.25 mg
price :
355 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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