antibody

MOUSE ANTI HUMAN THYROID STIMULATING HORMONE

MBS214263

1 mg

675 USD

monoclonal

mouse

nonconjugated

[IA3A5 (3A5)]

ELISA, enzyme immunoassay

Antibody

MOUSE ANTI HUMAN THYROID STIMULATING HORMONE

[THYROID STIMULATING HORMONE]

[thyrotropin subunit beta isoform 1; Thyrotropin subunit beta; thyrotropin subunit beta; thyrotropin beta chain; thyroid stimulating hormone, beta; Thyroid-stimulating hormone subunit beta; TSH-B; TSH-beta; Thyrotropin beta chain; INN: Thyrotropin alfa]

[TSHB; TSHB; TSH-B; TSH-BETA; TSH-B; TSH-beta]

TSHB_HUMAN

Monoclonal

IgG2a

[IA3A5 (3A5)]

Mouse

138

Thyroid Stimulating Hormone Beta Chain

Purified IgG - liquid

IgG concentration 1.0 mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

ELISA (EIA)

Perservative Stabilisers: 0.09% Sodium Azide (NaN 3 ). Preparation: Purified IgG prepared by affinity chromatography on Protein A

Buffer Solution: Phosphate buffered saline. Target Species: Human. Immunogen: Purified Human TSH.

Mouse anti Human thyroid stimulating hormone, clone IA3A5 is highly specific to thyroid stimulating hormone (TSH), a 28kDa pituitary hormone which stimulates thyroid growth and the production of thyroid hormone. This antibody does not cross react with human chorionic gonadotrophin (hCG), luteinizing hormone (hLH) or follicle stimulating hormone (hFSH).

115430099

NP_000540.2

NM_000549.4

P01222

10,624 Da

Amine-derived Hormones Pathway (160983); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Glycoprotein Hormones Pathway (160989)

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

TSHB: Indispensable for the control of thyroid structure and metabolism. Belongs to the glycoprotein hormones subunit beta family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 1p13. Cellular Component: extracellular region. Molecular Function: hormone activity. Biological Process: G-protein coupled receptor protein signaling pathway; anatomical structure morphogenesis; cellular protein metabolic process; cell-cell signaling; response to estrogen stimulus; peptide hormone processing; response to calcium ion; response to vitamin A. Disease: Hypothyroidism, Congenital, Nongoitrous, 4

1 mg

675 USD