catalog number :
MBS213978
products full name :
MOUSE ANTI HUMAN AMYLIN
products short name :
AMYLIN
other names :
islet amyloid polypeptide; Islet amyloid polypeptide; islet amyloid polypeptide; Islet amyloid polypeptide (diabetes-associated peptide; amylin); insulinoma amyloid peptide; islet amyloid polypeptide; Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide
other gene names :
IAPP; IAPP; DAP; IAP; DAP
uniprot entry name :
IAPP_HUMAN
form :
Tissue Culture Supernatant - liquid
storage stability :
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Immunohistology Frozen, Immunofluorescence (IF), Immunohistology Paraffin
app notes :
Immunohistology: This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Immunohistology - Frozen: Maximum Dilution: 1/100. Immunohistology - Paraffin: Maximum Dilution: 1/100
other info1 :
Perservative Stabilisers: 0.09% Sodium Azide
other info2 :
Immunogen: CATQRLANFLV coupled to tuberculin. Fusion Partners: Spleen cells from immunised BALB/c mouse were fused with cells of the mouse SP2/0 myeloma cell line. Target Species: Human
products description :
Mouse anti Human Amylin antibody, clone R10/99 recognizes the islet amyloid polypeptide (amylin). Mouse anti Human Amylin antibody, clone R10/99 is of high affinity, and stains islet amyloid peptide in intra-cellular insulin granules, intra-cellular amyloid and extra-cellular islet amyloid.
ncbi acc num :
NP_000406.1
ncbi gb acc num :
NM_000415.2
ncbi mol weight :
9,806 Da
ncbi pathways :
Amyloids Pathway 366238!!Calcitonin-like Ligand Receptors Pathway 106379!!Class B/2 (Secretin Family Receptors) Pathway 106378!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664!!Developmental Biology Pathway 477129!!Disease Pathway 530764!!G Alpha (s) Signalling Events Pathway 119549!!GPCR Downstream Signaling Pathway 119548!!GPCR Ligand Binding Pathway 161020!!Integrated Pancreatic Cancer Pathway 711360
ncbi summary :
The protein encoded by this gene is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity. [provided by RefSeq, Sep 2014]