catalog number :
MBS213386
products full name :
MOUSE ANTI HUMAN INTEGRIN ALPHA 9 BETA 1
products short name :
INTEGRIN ALPHA 9 BETA 1
other names :
integrin alpha-9; Integrin alpha-9; integrin alpha-9; integrin alpha-RLC; integrin, alpha 9; Integrin alpha-RLC
other gene names :
ITGA9; ITGA9; RLC; ITGA4L; ALPHA-RLC
uniprot entry name :
ITA9_HUMAN
specificity :
This item is specific for Integrin alpha 9/ beta 1, a receptor for VCAM1, cytotactin and osteopontin. In functional applications this clone has been shown to cause 100% inhibition of ?9ß1-mediated adhesion to the third fibronectin type III repeat in tenascin at <10ug/ml.
form :
Purified. Purified IgG - liquid
concentration :
IgG concentration 1.0 mg/ml
storage stability :
Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Flow cytometry (FC/FACS), Functional Assays (FN), Immunoprecipitation (IP)
other info2 :
Immunogen: Murine L cells transfected with human alpha-9 integrin. Buffer Solution: Phosphate buffered saline. Target Species: Human
products description :
MBS213386 is specific for Integrin alpha 9/ beta 1, a receptor for VCAM1, cytotactin and osteopontin. In functional applications this clone has been shown to cause 100% inhibition of alpha9beta1-mediated adhesion to the third fibronectin type III repeat in tenascin at
ncbi acc num :
NP_002198.2
ncbi gb acc num :
NM_002207.2
ncbi mol weight :
114,489 Da
ncbi pathways :
Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Axon Guidance Pathway (105688); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Developmental Biology Pathway (477129); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); ECM Proteoglycans Pathway (833812)
ncbi summary :
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq, Jul 2008]
uniprot summary :
ITGA9: Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G- I-E-L in cytotactin. Belongs to the integrin alpha chain family. Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 3p21.3. Cellular Component: plasma membrane; basal plasma membrane; integrin complex. Molecular Function: collagen binding; metal ion binding; laminin binding. Biological Process: integrin-mediated signaling pathway; neutrophil chemotaxis; axon guidance; extracellular matrix organization and biogenesis; wound healing; cell adhesion