MOUSE ANTI SHEEP CD230 | MyBioSource MBS213315 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI SHEEP CD230

catalog :

MBS213315

quantity :

0.1 mg

price :

615 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5121

reactivity :

sheep

application :

western blot, ELISA, enzyme immunoassay

product information

catalog number :

MBS213315

products type :

Antibody

products full name :

MOUSE ANTI SHEEP CD230

products short name :

CD230

other names :

major prion protein; Major prion protein; major prion protein; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); CD_antigen: CD230

products gene name :

CD230

other gene names :

PRNP; PRNP; Prp; SIP; PRPC; PRP; SIP; PrP

uniprot entry name :

PRIO_SHEEP

clonality :

Monoclonal

isotype :

IgG1

clone :

5121

host :

Mouse

reactivity :

Bovine, Cat (Expected from Sequence), Chimpanzee (Expected from Sequence), Dog (Expected from Sequence), Goat (Expected from Sequence), Gorilla (Expected from Sequence), Human (Expected from Sequence), Mouse (Expected from Sequence), Pig (Expected from Se

sequence length :

256

specificity :

Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal infectious neurodegenerative diseases of humans and animals. These diseases are biologically unique, as they are believed by some to be transmitted by an infectious agent comprised only of protein, with no nucleic acid component. Clinically, these diseases present with motor disturbances and behavioural changes. The major pathological changes seen are neuronal loss, vacuolation (spongiform change), proliferation and branching of glial cells, astrocytic proliferation and accumulation of the prion protein PrPSc, which can form amyloid plaques. CD230, also known as the prion protein (PrP) exists in two alternate forms; a normal cellular form (PrPc) and a disease-associated form (PrPSc).The normal and pathological forms of the prion protein have identical amino acid sequences and differ only in their folded tertiary structure and biochemical properties.This item will recognise PrPc and PrPSc. After denaturation/protease treatment this antibody recognises only the disease-associated form (PrPSc).

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 0.1 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

ELISA (EIA), Immunohistology Paraffin*, Western Blot (WB)

app notes :

ELISA: Minimum Dilution: 1/20; Maximum Dilution: 1/200;. Immunohistology - Paraffin: Minimum Dilution: 1/10; Maximum Dilution: 1/50; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. . Western Blotting: Minimum Dilution: 1/10; Maximum Dilution: 1/50

other info1 :

Perservative Stabilisers: 0.09% Sodium azide. Preparation: Purified IgG prepared by affinity chromatography on Protein A

other info2 :

Buffer Solution: Phosphate buffered saline. Target Species: Sheep

products description :

Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal infectious neurodegenerative diseases of humans and animals. These diseases are biologically unique, as they are believed by some to be transmitted by an infectious agent comprised only of protein, with no nucleic acid component. Clinically, these diseases present with motor disturbances and behavioural changes. The major pathological changes seen are neuronal loss, vacuolation (spongiform change), proliferation and branching of glial cells, astrocytic proliferation and accumulation of the prion protein PrPSc, which can form amyloid plaques. CD230, also known as the prion protein (PrP) exists in two alternate forms; a normal cellular form (PrPc) and a disease-associated form (PrPSc).The normal and pathological forms of the prion protein have identical amino acid sequences and differ only in their folded tertiary structure and biochemical properties.MBS213315 will recognise PrPc and PrPSc. After denaturation/protease treatment this antibody recognises only the disease-associated form (PrPSc).

ncbi gi num :

57164159

ncbi acc num :

NP_001009481.1

ncbi gb acc num :

NM_001009481.1

uniprot acc num :

P23907

ncbi mol weight :

27,915 Da

ncbi pathways :

Prion Diseases Pathway (1030862); Prion Diseases Pathway (100065)

size1 :

0.1 mg

price1 :

615 USD