MyBioSource

antibody

MOUSE ANTI MOUSE p53 (WILD TYPE)

MBS213197

0.1 mg

415 USD

monoclonal

mouse

mouse

immunoprecipitation

MBS213197

Antibody

MOUSE ANTI MOUSE p53 (WILD TYPE)

p53

cellular tumor antigen p53 isoform b; Cellular tumor antigen p53; cellular tumor antigen p53; mutant p53; p53 cellular tumor antigen; tumor suppressor p53; tumor supressor p53; transformation related protein 53; Tumor suppressor p53

p53

Trp53; Tp53; bbl; bfy; bhy; p44; p53; Tp53; P53; Trp53

P53_MOUSE

Monoclonal

IgG1

PAb246

Mouse

381

Purified. Purified IgG - liquid

IgG concentration 1.0 mg/ml

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

Immunohistology Frozen, Immunoprecipitation (IP)

Perservative Stabilisers: 10mM Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant

Immunogen: SV40 - transformed cell line BALBc SVA31E7 (1). Buffer Solution: Phosphate buffered saline. Target Species: Mouse

Mouse anti Mouse p53 (Wild Type) antibody, clone PAb246 recognizes wild type murine oncoprotein p53 of mW 50kD. The epitope recognized is between amino acids 88 and 109. p53 becomes tightly complexed to SV40 large T antigen in SV40 transformed cells, resulting in a greatly increased stability. In transformed murine 3T3 cells p53 levels may be 1,000 fold higher than in parental cells. PAb246 recognizes an epitope of p53 that is unstable in the absence of SV40 large T antigen.

187960040

NP_001120705.1

NM_001127233.1

P02340

43,155 Da

Amyotrophic Lateral Sclerosis (ALS) Pathway 83296!!Amyotrophic Lateral Sclerosis (ALS) Pathway 511!!Androgen Receptor Signaling Pathway 198319!!Apoptosis Pathway 198339!!Apoptosis Pathway 83257!!Apoptosis Pathway 470!!Apoptosis Signaling Pathway 522973!!Autodegradation Of The E3 Ubiquitin Ligase COP1 Pathway 1110070!!Basal Cell Carcinoma Pathway 83306!!Basal Cell Carcinoma Pathway 525

This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

0.1 mg

415 USD