catalog number :
MBS213146
products full name :
MOUSE ANTI HUMAN CD64
products short name :
CD64
other names :
high affinity immunoglobulin gamma Fc receptor I; High affinity immunoglobulin gamma Fc receptor I; high affinity immunoglobulin gamma Fc receptor I; Fc fragment of IgG, high affinity Ia, receptor for (CD64); Fc gamma receptor; Fc-gamma RI; Fc-gamma receptor I A1; IgG Fc receptor I; fc-gamma RIA; fcgammaRIa; Fc fragment of IgG, high affinity Ia, receptor (CD64); Fc-gamma RI; FcRI; Fc-gamma RIA; FcgammaRIa; CD_antigen: CD64
products gene name :
CD64
other gene names :
FCGR1A; FCGR1A; CD64; FCRI; CD64A; IGFR1; FCG1; FCGR1; IGFR1; IgG Fc receptor I; FcRI; FcgammaRIa
uniprot entry name :
FCGR1_HUMAN
form :
Purified. Purified IgG - liquid
concentration :
IgG concentration 1.0 mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Flow cytometry (FC/FACS)
app notes :
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/100
other info1 :
Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
other info2 :
Immunogen: Human monocytes. Fusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0-Ag14 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Human
products description :
Mouse anti Human CD64 antibody, clone 10.1 recognizes the human CD64 cell surface antigen, a 75kD glycoprotein expressed by monocytes. The antigen acts as a high affinity receptor for human IgG, and is also known as FcRI. Mouse anti Human CD64 antibody, clone 10.1 blocks binding of immunoglobulin to FcRI.
ncbi acc num :
NP_000557.1
ncbi gb acc num :
NM_000566.3
ncbi mol weight :
38,795 Da
ncbi pathways :
Adaptive Immune System Pathway (366160); Antigen Processing-Cross Presentation Pathway (477122); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Cross-presentation Of Soluble Exogenous Antigens (endosomes) Pathway (477126); Cytokine Signaling In Immune System Pathway (366171); FCGR Activation Pathway (771578); Fc Gamma R-mediated Phagocytosis Pathway (114228); Fc Gamma R-mediated Phagocytosis Pathway (106590); Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway (771577); Hematopoietic Cell Lineage Pathway (83078)
ncbi summary :
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]
uniprot summary :
FCGR1A: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Belongs to the immunoglobulin superfamily. FCGR1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q21.2-q21.3. Cellular Component: early endosome membrane; plasma membrane; integral to membrane. Molecular Function: protein binding; IgG binding; receptor signaling protein activity. Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; innate immune response; immune response; signal transduction; phagocytosis, engulfment