antibody

MOUSE ANTI HUMAN CD36

MBS213128

0.2 mg

415 USD

monoclonal

mouse

nonconjugated

SMØ

flow cytometry, FACS

Antibody

MOUSE ANTI HUMAN CD36

CD36

platelet glycoprotein 4 isoform 1; Platelet glycoprotein 4; platelet glycoprotein 4; CD36 antigen (collagen type I receptor, thrombospondin receptor); GPIIIB; PAS IV; PAS-4 protein; cluster determinant 36; fatty acid translocase; glycoprotein IIIb; leukocyte differentiation antigen CD36; platelet glycoprotein IV; scavenger receptor class B, member 3; CD36 molecule (thrombospondin receptor); Fatty acid translocase; FAT; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; Platelet collagen receptor; Platelet glycoprotein IV; GPIV; Thrombospondin receptor; CD_antigen: CD36

CD36

CD36; CD36; FAT; GP4; GP3B; GPIV; CHDS7; PASIV; SCARB3; BDPLT10; GP3B; GP4; FAT; GPIIIB; GPIV

CD36_HUMAN

Monoclonal

IgM

SMØ

Mouse

472

Purified. Purified IgM - liquid

IgM concentration 1 mg/ml

Store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

Immunohistology Frozen, Flow cytometry (FC/FACS)

Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood. Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/100

Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgM prepared by ammonium sulphate precipitation from tissue culture supernatant

Immunogen: Human tonsil cells and peripheral blood mononuclear cells. Buffer Solution: Phosphate buffered saline. Target Species: Human

Mouse anti Human CD36 antibody, clone SM˜ recognizes the CD36 antigen, an 88kD cell surface glycoprotein expressed by platelets, monocytes/macrophages and also by some microvascular endothelium and erythroid precursors. CD36 is the receptor for thrombospondin. When expressed by monocytes and macrophages, CD36 acts as a receptor for oxidized LDL and for apoptotic polymorphonuclear cells. Mouse anti Human CD36 antibody, clone SM˜ partially inhibits collagen induced platelet aggregation and macrophage ingestion of apoptotic human neutrophils. It has been reported that this antibody may activate platelets as measured by fibrinogen binding, P-Selectin expression and Annexin V binding - for further details please contact our Technical Services team. Mouse anti Human CD36 antibody, clone SM˜ is also reported to block interaction of oxidised low-density lipoprotein (OXLDL) with CD36 (Sugihara et al.1992).

48375178

NP_000063.2

NM_000072.3

P16671

46,090 Da

AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Activated TLR4 Signalling Pathway (106400); Adaptive Immune System Pathway (366160); Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Antigen Processing-Cross Presentation Pathway (477122); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway (477123)

The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]

CD36: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7). Belongs to the CD36 family. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Cell adhesion. Chromosomal Location of Human Ortholog: 7q11.2. Cellular Component: Golgi apparatus; extracellular space; platelet alpha granule membrane; cell surface; membrane; integral to plasma membrane; plasma membrane; phagocytic vesicle; lipid raft; external side of plasma membrane. Molecular Function: low-density lipoprotein receptor activity; transforming growth factor beta binding; low-density lipoprotein binding; lipid binding; high-density lipoprotein binding. Biological Process: positive regulation of blood coagulation; positive regulation of interleukin-12 production; cGMP-mediated signaling; phagocytosis, recognition; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription factor import into nucleus; low density lipoprotein mediated signaling; antigen processing and presentation of peptide antigen via MHC class I; sequestering of lipid; platelet degranulation; cell surface receptor linked signal transduction; positive regulation of MAPKKK cascade; antigen processing and presentation of exogenous peptide antigen via MHC class I; positive regulation of cell-matrix adhesion; cell adhesion; toll-like receptor 4 signaling pathway; platelet activation; receptor-mediated endocytosis; cholesterol transport; positive regulation of I-kappaB kinase/NF-kappaB cascade; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-positive bacterium; positive regulation of peptidyl-tyrosine phosphorylation; lipoprotein transport; toll-like receptor signaling pathway; innate immune response; lipid metabolic process; blood coagulation; positive regulation of phagocytosis, engulfment; nitric oxide mediated signal transduction; plasma membrane long-chain fatty acid transport; apoptotic cell clearance. Disease: Platelet Glycoprotein Iv Deficiency; Coronary Heart Disease, Susceptibility To, 7; Malaria, Susceptibility To

0.2 mg

415 USD