catalog number :
MBS213083
products full name :
MOUSE ANTI HUMAN CD11b
products short name :
CD11b
other names :
integrin alpha-M isoform 2; Integrin alpha-M; integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; antigen CD11b (p170); cell surface glycoprotein MAC-1 subunit alpha; leukocyte adhesion receptor MO1; macrophage antigen alpha polypeptide; neutrophil adherence receptor alpha-M subunit; integrin, alpha M (complement component 3 receptor 3 subunit); CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD_antigen: CD11b
products gene name :
CD11b
other gene names :
ITGAM; ITGAM; CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6; CD11B; CR3A
uniprot entry name :
ITAM_HUMAN
reactivity :
Baboon, Cynomolgus monkey, Rhesus Monkey
form :
Purified. Purified IgG - liquid
concentration :
IgG concentration 1 mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Immunohistology Frozen*, Flow cytometry (FC/FACS), Immunoprecipitation (IP)
app notes :
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood . Immunohistology - Frozen: Minimum Dilution: 1/100; Maximum Dilution: 1/1000; Application Note: The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. MyBioSource recommends the use of acetone fixation for frozen sections. . Flow Cytometry: Minimum Dilution: 1/10; Maximum Dilution: 1/100
other info1 :
Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
other info2 :
Immunogen: Rheumatoid synovial cells and human monocytes. Histology Positive Control Tissue: Human tonsil. Fusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the mouse Sp2/0 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Human
ncbi acc num :
NP_000623.2
ncbi gb acc num :
NM_000632.3
ncbi mol weight :
127,307 Da
ncbi pathways :
Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480!!Cell Surface Interactions At The Vascular Wall Pathway 106062!!Extracellular Matrix Organization Pathway 576262!!Focal Adhesion Pathway 198795!!Hematopoietic Cell Lineage Pathway 83078!!Hematopoietic Cell Lineage Pathway 489!!Hemostasis Pathway 106028
ncbi summary :
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]