product summary
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company name :
MyBioSource
product type :
antibody
product name :
MOUSE ANTI HUMAN IgG1 (Fc)
catalog :
MBS213064
quantity :
0.2 mg
price :
475 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
8c/6-39 (HP6091)
more info or order :
product information
catalog number :
MBS213064
products type :
Antibody
products full name :
MOUSE ANTI HUMAN IgG1 (Fc)
products short name :
IgG1
other names :
Ig gamma-1 chain C region, partial; Ig gamma-1 chain C region; immunoglobulin heavy constant gamma 1 (G1m marker)
products gene name :
IgG1
other gene names :
IGHG1; IGHG1
uniprot entry name :
IGHG1_HUMAN
clonality :
Monoclonal
isotype :
IgG2a
clone :
8c/6-39 (HP6091)
host :
Mouse
sequence length :
330
specificity :
This clone recognizes an epitope within the CH2 domain of the Fc region in Human IgG1. It is negative on IgG2, IgG3, IgG4, free kappa or free lambda, IgM, IgA1 (lambda), IgA2 (kappa) and IgD.
form :
Purified. Purified IgG - liquid
concentration :
IgG concentration 1.0 mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Immunohistology Frozen*, Immunodiffusion (ID)
app notes :
Immunohistology - Frozen: Application Note: The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. MyBioSource recommends the use of acetone fixation for frozen sections.
other info1 :
Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
other info2 :
Immunogen: Purified Human IgG1. Fusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the SP2/0 AG14 mouse myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Human
products description :
This clone recognizes an epitope within the CH2 domain of the Fc region in Human IgG1. It is negative on IgG2, IgG3, IgG4, free kappa or free lambda, IgM, IgA1 (lambda), IgA2 (kappa) and IgD.
ncbi gi num :
121039
ncbi acc num :
P01857.1
uniprot acc num :
P01857
ncbi mol weight :
36,106 Da
ncbi pathways :
IL4-mediated Signaling Events Pathway (137933)
uniprot summary :
IGHG1: Defects in IGHG1 are a cause of multiple myeloma (MM). MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4. Protein type: Immunoglobulin superfamily. Chromosomal Location of Human Ortholog: 14q32.33. Cellular Component: extracellular space; extracellular region. Molecular Function: protein binding; antigen binding. Biological Process: innate immune response; complement activation, classical pathway; complement activation. Disease: Myeloma, Multiple
size1 :
0.2 mg
price1 :
475 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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