MOUSE ANTI RAT CD172a | MyBioSource MBS212963 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI RAT CD172a

catalog :

MBS212963

quantity :

0.1 mg

price :

190 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

OX-41

reactivity :

rat

application :

flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS212963

products type :

Antibody

products full name :

MOUSE ANTI RAT CD172a

products short name :

CD172a

other names :

tyrosine-protein phosphatase non-receptor type substrate 1; Tyrosine-protein phosphatase non-receptor type substrate 1; tyrosine-protein phosphatase non-receptor type substrate 1; Brain immunoglobulin like protein with tyrosine - based activation motifs; CD172 antigen-like family member A; Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1); Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1); brain Ig-like molecule with tyrosine-based activation motifs; inhibitory receptor SHPS-1; macrophage fusion receptor; macrophage membrane protein MFP150; signal-regulatory protein alpha-1; sirp-alpha-1; signal-regulatory protein alpha; Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; Macrophage membrane protein MFP150; Signal-regulatory protein alpha-1; Sirp-alpha-1; CD_antigen: CD172a

products gene name :

CD172a

other gene names :

Sirpa; Sirpa; Bit; Ptpns1; SHPS-1; Bit; Mfr; Ptpns1; Shps1; Sirp; SHP substrate 1; SHPS-1; Bit; Sirp-alpha-1

uniprot entry name :

SHPS1_RAT

clonality :

Monoclonal

isotype :

IgG2a

clone :

OX-41

host :

Mouse

sequence length :

509

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Frozen, Flow cytometry (FC/FACS), Immunohistology Paraffin*

app notes :

Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Flow Cytometry: Minimum Dilution: 1/100; Maximum Dilution: 1/200. Immunohistology - Paraffin: Application Note: This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase.

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

other info2 :

Buffer Solution: Phosphate buffered saline. Target Species: Rat

products description :

Mouse anti Rat CD172a antibody, clone OX-41 recognizes rat CD172a, also known as Signal regulatory protein (SIRP). CD172a is expressed selectively by myeloid cells and by neurons. MRC OX-41 binds to a different epitope on SIRP than ED9. It does not block the interaction of CD172a - CD47.

ncbi gi num :

31543529

ncbi acc num :

NP_037148.2

ncbi gb acc num :

NM_013016.2

uniprot acc num :

P97710

ncbi mol weight :

55,691 Da

ncbi pathways :

Cell Surface Interactions At The Vascular Wall Pathway (1120553); Cell-Cell Communication Pathway (1121445); DAP12 Interactions Pathway (1121612); Hemostasis Pathway (1120520); IL-1 Signaling Pathway (198458); Immune System Pathway (1121507); Innate Immune System Pathway (1121536); Osteoclast Differentiation Pathway (193140); Osteoclast Differentiation Pathway (193096); Signal Regulatory Protein (SIRP) Family Interactions Pathway (1121455)

ncbi summary :

plays a role in macrophage fusion [RGD, Feb 2006]

uniprot summary :

SHPS1: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR. Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B. Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Cell adhesion; Cell surface; Motility/polarity/chemotaxis; Receptor, misc. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: protein phosphorylated amino acid binding; protein binding; SH3 domain binding. Biological Process: cell migration; positive regulation of phagocytosis; cell-matrix adhesion; actin filament organization; cytoskeleton organization and biogenesis; hemopoietic progenitor cell differentiation; phagocytosis, recognition; phagocytosis, engulfment

size1 :

0.1 mg

price1 :

190 USD

more info or order :

MyBioSource product webpage