antibody

MOUSE ANTI HUMAN C7

MBS212935

0.1 mg

500 USD

monoclonal

mouse

nonconjugated

030-113.7.5.4

western blot, ELISA, enzyme immunoassay

Antibody

MOUSE ANTI HUMAN C7

C7

complement component C7; Complement component C7; complement component C7; complement component 7

C7

C7; C7

CO7_HUMAN

Monoclonal

IgG1

030-113.7.5.4

Mouse

843

Purified. Purified IgG - liquid

IgG concentration 1.0 mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

ELISA (EIA), Functional Assays (FN), Western Blot (WB)

Perservative Stabilisers: 0.1% Sodium Azide (NaN3). Preparation: Purified IgG prepared by affinity chromatography on Protein A

Buffer Solution: Borate buffered saline. Target Species: Human. Immunogen: Purified human C7

Mouse anti Human C7 antibody, clone 030-113.7.5.4 recognises complement component 7 (C7), a 110 kDa glycoprotein present in the blood serum. The factor I domain of C7 binds the C terminus of the C5 alpha-chain, acting as a membrane anchor. This enables the assembly of the complement membrane attack complex (MAC) and consequent complement lytic activity. C7 deficiency is associated with increased susceptibility to recurrent infections, in particular by Neisseria meningitides. Mouse anti Human C7 antibody, clone 030-113.7.5.4 does not recognie membrane bound complement membrane attack complex. Mouse anti Human C7 antibody, clone 030-113.7.5.4 inhibits lysis of sensitised sheep erythrocytes. Removal of Sodium Azide is recommended prior to use in functional assays. MyBioSource recommend the use of EQU003 for this purpose.

45580688

NP_000578.2

NM_000587.2

P10643

93,518 Da

Complement Activation, Classical Pathway (198823); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Immune System Pathway (106386); Innate Immune System Pathway (106387); Prion Diseases Pathway (101144); Prion Diseases Pathway (100065); Regulation Of Complement Cascade Pathway (576254)

C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008]

C7: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 5p13. Cellular Component: membrane attack complex; extracellular region. Biological Process: cellular sodium ion homeostasis; cytolysis; complement activation, alternative pathway; regulation of complement activation; innate immune response; complement activation, classical pathway; complement activation. Disease: Complement Component 7 Deficiency

0.1 mg

500 USD