MyBioSource

antibody

MOUSE ANTI HUMAN D-DIMER

MBS212857

0.2 mg

430 USD

monoclonal

mouse

human

western blot, enzyme immunoassay, ELISA

MBS212857

Antibody

MOUSE ANTI HUMAN D-DIMER

D-dimer

fibrinogen alpha chain isoform alpha-E preproprotein; Fibrinogen alpha chain; fibrinogen alpha chain; fibrinogen, A alpha polypeptide; fibrinogen alpha chain; N/A

D-DIMER

FGA; FGA; Fib2; N/A

FIBA_HUMAN

Monoclonal

IgG2b

DD3

Mouse

866

Purified. Purified IgG - liquid

IgG concentration 1.0mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

ELISA (EIA), Western Blot (WB)

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein A

Immunogen: Homogenised fibrin clot. Fusion Partners: Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Human

Mouse anti Human D-Dimer antibody, clone DD3 recognizes human D-dimer and high molecular weight fibrin degradation products, but does not cross-react with fibrinogen (D-monomer). D-dimers are the principle degradation products of cross-linked fibrin, released into the bloodstream following the digestion of fibrin clots (thrombus) by the enzyme plasmin, and thus measurement of the level of D-dimer in plasma, can be used as an indication of thrombotic disorders. Conditions in which levels of D-dimer are elevated include deep vein thrombosis (DVT), venous thromboembolism (VTE), cardiovascular disease and disseminated intravascular coagulation (DIC), a possible acute condition arising from surgical operations, septic shock and liver disease.

4503689

NP_000499.1

NM_000508.3

69,757 Da

Amyloids Pathway 366238!!Blood Clotting Cascade Pathway 198840!!Common Pathway 106060!!Complement And Coagulation Cascades Pathway 83073!!Complement And Coagulation Cascades Pathway 484!!Disease Pathway 530764!!Extracellular Matrix Organization Pathway 576262!!Formation Of Fibrin Clot (Clotting Cascade) Pathway 106057!!GRB2:SOS Provides Linkage To MAPK Signaling For Integrins Pathway 106055!!Hemostasis Pathway 106028

The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq, Jul 2008]

0.2 mg

430 USD