catalog number :
MBS212822
products full name :
RAT ANTI EPSTEIN-BARR VIRUS LMP2A
products short name :
[EPSTEIN-BARR VIRUS LMP2A]
products name syn :
[EBV]
form :
Purified. Purified IgG - liquid
concentration :
IgG concentration 1.0 mg/ml
storage stability :
Store at 4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Immunohistology Paraffin*, Western Blot (WB)
app notes :
Western Blotting: < 1/100- 1/1000
other info1 :
Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant. Carrier Free: Yes. Fusion Partners: Spllen cells from immunized Lou/C rats were fused with cells of the P3X63.Ag8.653 myeloma cell line.
other info2 :
Immunogen: Bacterial TrpE-LMP2A fusion protein. Fusion Partners: Spleen cells from immunised Lou/c rats were fused with cells of the P3X63.Ag8.653 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Viral
products description :
Rat anti Epstein-Barr Virus LMP2A antibody, clone 15F9 recognizes latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV). EBV is a human herpesvirus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals. MBS212822 specifically recognizes LMP2A and does not cross react with LMP2B.