product summary
request information :
company name :
MyBioSource
product type :
antibody
product name :
RAT ANTI MOUSE CD86
catalog :
MBS212820
quantity :
0.1 mg
price :
205 USD
clonality :
monoclonal
host :
rat
reactivity :
mouse
application :
flow cytometry, FACS
more info or order :
product information
catalog number :
MBS212820
products type :
Antibody
products full name :
RAT ANTI MOUSE CD86
products short name :
CD86
other names :
T-lymphocyte activation antigen CD86; T-lymphocyte activation antigen CD86; T-lymphocyte activation antigen CD86; activation B7-2 antigen; early T cell costimulatory molecule-1; early T-cell costimulatory molecule 1; CD86 antigen; Activation B7-2 antigen; Early T-cell costimulatory molecule 1; ETC-1; CD_antigen: CD86
products gene name :
CD86
other gene names :
Cd86; Cd86; B7; B70; MB7; B7-2; B7.2; CLS1; Ly58; ETC-1; Ly-58; MB7-2; Cd28l2; TS/A-2; ETC-1
uniprot entry name :
CD86_MOUSE
clonality :
Monoclonal
isotype :
IgG2b
clone :
PO3
host :
Rat
sequence length :
303
form :
Purified. Purified IgG - liquid
concentration :
IgG concentration 1.0 mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Flow cytometry (FC/FACS)
app notes :
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
other info1 :
Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
other info2 :
Immunogen: Mouse B-cell line, BCL1. Fusion Partners: Spleen cells from immunised Sprague Dawley rats were fused with cells of the P3U1 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Mouse
products description :
Rat anti mouse CD86 recognizes mouse CD86 (B7-2), an 80kD cell surface glycoprotein which is a member of the CD28/B7 family. In mouse CD86 is expressed at high levels on peripheral blood monocytes and dendritic cells, and at low levels on resting B and T-lymphocytes. Expression of CD86, on these cell populations, can be increased upon activation. CD86 has been identified, along with CD80 (B7-1), as a ligand for CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA4). CD28 and CTLA4 are two receptors that have opposing functions in T-cell stimulation. Interaction of CD86 with CD28 promotes a number of T-cell activities, whereas the binding of CD86 to CTLA4 inhibits T-cell responses. The PO3 antibody has been reported to block some co-stimulatory functions of CD86 (Nakajima et al. 1997).
ncbi gi num :
161484599
ncbi acc num :
NP_062261.3
ncbi gb acc num :
NM_019388.3
uniprot acc num :
P42082
ncbi mol weight :
33,962 Da
ncbi pathways :
Adaptive Immune System Pathway 1110669!!Allograft Rejection Pathway 83316!!Allograft Rejection Pathway 535!!Autoimmune Thyroid Disease Pathway 83314!!Autoimmune Thyroid Disease Pathway 533!!CD28 Co-stimulation Pathway 1110676!!CD28 Dependent PI3K/Akt Signaling Pathway 1110677!!CD28 Dependent Vav1 Pathway 1110678!!CTLA4 Inhibitory Signaling Pathway 1110679!!Cell Adhesion Molecules (CAMs) Pathway 83266
size :
0.1 mg
price :
205 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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