RAT ANTI MOUSE CD321 | MyBioSource MBS212721 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RAT ANTI MOUSE CD321

catalog :

MBS212721

quantity :

0.1 mg

price :

205 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

H202-106

reactivity :

mouse

application :

immunoprecipitation, flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS212721

products type :

Antibody

products full name :

RAT ANTI MOUSE CD321

products short name :

CD321

other names :

junctional adhesion molecule A; Junctional adhesion molecule A; junctional adhesion molecule A; BV11 antigen; F11 receptor/F11R; junction cell adhesion molecule A; junction cell adhesion molecule1; junctional adhesion molecule 1; F11 receptor; Junctional adhesion molecule 1; JAM-1; CD_antigen: CD321

products gene name :

CD321

other gene names :

F11r; F11r; JAM; Jcam; JAM-1; JAM-A; Jcam1; Ly106; ESTM33; AA638916; 9130004G24; Jam1; Jcam; Jcam1; JAM-A; JAM-1

uniprot entry name :

JAM1_MOUSE

clonality :

Monoclonal

isotype :

IgG1

clone :

H202-106

host :

Rat

sequence length :

300

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Frozen, Flow cytometry (FC/FACS), Immunoprecipitation (IP)

app notes :

Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Flow Cytometry: Minimum Dilution: 1/100; Maximum Dilution: 1/200

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

other info2 :

Immunogen: MTE1/MTE2 stromal cell lines. Fusion Partners: Cells from immunised Lou rats were fused with cells of the X63 mouse myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Mouse

products description :

Rat anti Mouse CD321 antibody, clone H202-106 recognizes murine CD321, which is also known as junctional adhesion molecule 1 (JAM-1). CD321 is a 32-41kD glycoprotein, which shares similarities with related proteins JAM-2 and JAM-3. CD321 is a multifunctional protein that is primarily expressed by platelets, endothelial and epithelial cells. The CD321 protein co-localises with tight junction molecules in both epithelial and endothelial cells and plays an important role in the regulation of junctional integrity and permeability. In addition, CD321 is a ligand for the integrin LFA-1 and is also involved in the transmigration of leucocytes.

ncbi gi num :

27734847

ncbi acc num :

NP_766235.1

ncbi gb acc num :

NM_172647.2

uniprot acc num :

O88792

ncbi mol weight :

32,424 Da

ncbi pathways :

Cell Adhesion Molecules (CAMs) Pathway (83266); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Junction Organization Pathway (1110290); Cell Surface Interactions At The Vascular Wall Pathway (1110059); Cell-Cell Communication Pathway (1110289); Cell-cell Junction Organization Pathway (1110291); Disease Pathway (1111319); Extracellular Matrix Organization Pathway (1110302); Hemostasis Pathway (1110026); Integrin Cell Surface Interactions Pathway (1110318)

uniprot summary :

JAM-A: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. Belongs to the immunoglobulin superfamily. Protein type: Cell adhesion; Membrane protein, integral. Cellular Component: microtubule cytoskeleton; tight junction; membrane; integral to membrane; plasma membrane; cytoplasmic vesicle; intercellular junction; cell junction. Molecular Function: protein binding; PDZ domain binding. Biological Process: epithelial cell differentiation; viral reproduction; actomyosin structure organization and biogenesis; cell adhesion; positive regulation of blood pressure; intestinal absorption

size1 :

0.1 mg

price1 :

205 USD

more info or order :

MyBioSource product webpage