MOUSE ANTI AURORA-A KINASE | MyBioSource MBS212609 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI AURORA-A KINASE

catalog :

MBS212609

quantity :

0.1 mg

price :

440 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

35C1

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

product information

catalog number :

MBS212609

products type :

Antibody

products full name :

MOUSE ANTI AURORA-A KINASE

products short name :

AURORA-A KINASE

other names :

aurora kinase A; Aurora kinase A; aurora kinase A; ARK-1; Aurora-A kinase; IPL1-related kinase; aurora 2; aurora-related kinase 1; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; breast tumor-amplified kinase; breast-tumor-amplified kinase; hARK1; protein phosphatase 1, regulatory subunit 47; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine-protein kinase 15; serine/threonine-protein kinase 6; serine/threonine-protein kinase aurora-A; aurora kinase A; Aurora 2; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; hARK1; Breast tumor-amplified kinase; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A

other gene names :

AURKA; AURKA; AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; AURORA2; PPP1R47; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6; ARK-1; Aurora-related kinase 1; hARK1

uniprot entry name :

AURKA_HUMAN

clonality :

Monoclonal

isotype :

IgG2b

clone :

35C1

host :

Mouse

reactivity :

Mouse

sequence length :

403

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB)

app notes :

Western Blot: This item detects a band of approximately 46kDa in human HeLa and mouse M-ICc12 cell lysates. Western Blotting: Minimum Dilution: 1/500; Maximum Dilution: 1/1000

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

other info2 :

Histology Positive Control Tissue: Human 293 and mouse LLC1 cell lines. Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

Mouse anri Human Aurora -A kinase monoclonal antibody, clone 35C1 recognizes human Aurora-A kinase also known as Aurora 2, breast tumor-amplified kinase and serine/threonine-protein kinase 6 or 15. Aurora kinase A is member of the Ser/Thr protein kinase family containing a single protein kinase domain, has a molecular weight of ~46kDa and is involved in mitotic spindle assembly (Ducat et al. 2004). Aurora-A kinase is reported to be overexpressed in many epithelial cancers and is thought to play an important role in tumourigenesis (Katayama et al. 2003). Aurora A kinase appears to facilitate phosphorylation of centrin and co-localizes with it at centrosomes with maximum expression through prophase to late metaphase (Lukasiewicz et al. 2011). Mouse anti human Aurora-A kinase, clone 35C1 specifically recognizes an epitope within the non-catalytic N-terminal domain of Aurora-A. Clone 35C1 does not inhibit Aurora-A kinase activity (Cremet et al. 2003).

ncbi gi num :

38327562

ncbi acc num :

NP_003591.2

ncbi gb acc num :

NM_003600.2

uniprot acc num :

O14965

ncbi mol weight :

45,809 Da

ncbi pathways :

APC/C-mediated Degradation Of Cell Cycle Proteins Pathway 105825!!APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway 105835!!Aurora A Signaling Pathway 137925!!Aurora B Signaling Pathway 138080!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!G2/M Transition Pathway 105801!!Gastric Cancer Network 1 Pathway 760635!!Integrated Breast Cancer Pathway 219801!!Mitotic G2-G2/M Phases Pathway 160942

ncbi summary :

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

size :

0.1 mg

price :

440 USD