RAT ANTI CCT DELTA | MyBioSource MBS212545 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

RAT ANTI CCT DELTA

catalog :

MBS212545

quantity :

0.1 mg

price :

500 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

PK/9/86b

reactivity :

human, mouse, cow

application :

western blot, immunoprecipitation, EMSA

product information

catalog number :

MBS212545

products type :

Antibody

products full name :

RAT ANTI CCT DELTA

products short name :

CCT DELTA

other names :

T-complex protein 1 subunit delta isoform b; T-complex protein 1 subunit delta; T-complex protein 1 subunit delta; TCP-1-delta; chaperonin containing t-complex polypeptide 1, delta subunit; stimulator of TAR RNA-binding; chaperonin containing TCP1, subunit 4 (delta); CCT-delta; Stimulator of TAR RNA-binding

products gene name :

CCT DELTA

other gene names :

CCT4; CCT4; SRB; Cctd; CCT-DELTA; CCTD; SRB; TCP-1-delta

uniprot entry name :

TCPD_HUMAN

clonality :

Monoclonal

isotype :

IgG2b

clone :

PK/9/86b

host :

Rat

reactivity :

Bovine, Human, Mouse

sequence length :

509

specificity :

This item recognises the delta polypeptide of the CCT chaperonin molecule complex. The intact CCT complex is composed of eight polypeptides in a double-ring structure. CCT is important within cells in aiding the folding of proteins including actin, tubulin and the VHL tumour suppressor protein.

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Gel Super Shift Assays (GS), Immunoprecipitation (IP), Western Blot (WB)

app notes :

Western Blot: This item detects a band of approximately 60kD in Hela cell lysates. Western Blotting: Minimum Dilution: 1/500; Maximum Dilution: 1/1000

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

other info2 :

Buffer Solution: Phosphate buffered saline

products description :

MBS212545 recognises the delta polypeptide of the CCT chaperonin molecule complex. The intact CCT complex is composed of eight polypeptides in a double-ring structure. CCT is important within cells in aiding the folding of proteins including actin, tubulin and the VHL tumour suppressor protein.

ncbi gi num :

375477430

ncbi acc num :

NP_001243650.1

ncbi gb acc num :

NM_001256721.1

uniprot acc num :

P50991

ncbi mol weight :

54,720 Da

ncbi pathways :

Assembly Of The Primary Cilium Pathway (1127502); Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway (106247); BBSome-mediated Cargo-targeting To Cilium Pathway (1127506); Cargo Trafficking To The Periciliary Membrane Pathway (1127504); Chaperonin-mediated Protein Folding Pathway (106242); Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway (106243); Folding Of Actin By CCT/TriC Pathway (106246); Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway (106245); Metabolism Of Proteins Pathway (106230); Organelle Biogenesis And Maintenance Pathway (1127494)

ncbi summary :

The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]

uniprot summary :

CCT-delta: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. Belongs to the TCP-1 chaperonin family. Protein type: Chaperone. Chromosomal Location of Human Ortholog: 2p15. Cellular Component: nucleoplasm; chaperonin-containing T-complex; centrosome; microtubule; cytoplasm; melanosome; cytosol. Molecular Function: protein binding; unfolded protein binding; ATP binding. Biological Process: de novo posttranslational protein folding; cellular protein metabolic process; protein folding; binding of sperm to zona pellucida

size1 :

0.1 mg

price1 :

500 USD