This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
MOUSE ANTI HUMAN CD284
catalog :
MBS212470
quantity :
0.2 mg
price :
440 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
HTA125
reactivity :
human, dog, Rhesus monkey
application :
western blot, immunoprecipitation, flow cytometry, FACS
product information
catalog number :
MBS212470
products type :
Antibody
products full name :
MOUSE ANTI HUMAN CD284
products short name :
CD284
other names :
toll-like receptor 4 isoform C; Toll-like receptor 4; toll-like receptor 4; hToll; homolog of Drosophila toll; toll-like receptor 4; hToll; CD_antigen: CD284
products gene name :
CD284
other gene names :
TLR4; TLR4; TOLL; CD284; TLR-4; ARMD10
uniprot entry name :
TLR4_HUMAN
clonality :
Monoclonal
isotype :
IgG2a
clone :
HTA125
host :
Mouse
reactivity :
Dog, Guinea Pig, Pig, Rhesus Monkey
sequence length :
799
form :
Purified. Purified IgG - liquid
concentration :
IgG concentration 1.0 mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Flow cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB)
app notes :
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood. Flow Cytometry: Minimum Dilution: 1/10; Maximum Dilution: 1/25
other info1 :
Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
other info2 :
Immunogen: Ba/F3 cell line expressing TLR4 (CD284). Fusion Partners: Spleen cells from immunised Balb/c mice were fused with cells of the mouse SP2/0 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Human
products description :
Mouse anti Human CD284 antibody, clone HTA125 recognizes the human Toll like receptor 4 (TLR4) cell surface antigen. TLR4, also known as CD284, has been demonstrated to act as a receptor for LPS on human monocytes and macrophages. TLR4 signalling of LPS stimulation requires the presence of the MD-2 molecule. TLR4 is weakly expressed by resting cells, but is upregulated following stimulation with LPS. This antibody has been demonstrated to block activation of monocytes with LPS. MyBioSource recommend the use of MBS211211 for this purpose.
ncbi gi num :
4507533
ncbi acc num :
NP_003257.1
ncbi gb acc num :
NM_003266.3
uniprot acc num :
O00206
ncbi mol weight :
73,301 Da
ncbi pathways :
Activated TLR4 Signalling Pathway 106400!!Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway 187088!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Corticotropin-releasing Hormone Pathway 920957!!HIF-1 Signaling Pathway 695200!!Hepatitis B Pathway 694606!!IKK Complex Recruitment Mediated By RIP1 Pathway 187090
ncbi summary :
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
size :
0.2 mg
price :
440 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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