MOUSE ANTI HUMAN HLA G | MyBioSource MBS212455 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI HUMAN HLA G

catalog :

MBS212455

quantity :

0.2 mg

price :

530 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MEM-G/1

reactivity :

human

application :

western blot

product information

catalog number :

MBS212455

products type :

Antibody

products full name :

MOUSE ANTI HUMAN HLA G

products short name :

HLA G

other names :

HLA class I histocompatibility antigen, alpha chain G; HLA class I histocompatibility antigen, alpha chain G; HLA class I histocompatibility antigen, alpha chain G; HLA G antigen; HLA class I molecule; HLA-G histocompatibility antigen, class I, G; MHC class I antigen G; b2 microglobulin; major histocompatibility complex, class I, G; HLA G antigen; MHC class I antigen G

products gene name :

HLA G

other gene names :

HLA-G; HLA-G; MHC-G; HLA-6.0; HLAG

uniprot entry name :

HLAG_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

MEM-G/1

host :

Mouse

sequence length :

338

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Paraffin*, Western Blot (WB)*

app notes :

Immunohistology - Paraffin: Minimum Dilution: 1/60; Maximum Dilution: 1/100; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. . Western Blotting: Application Note: MEM-G/1 recognizes HLA G under reducing conditions

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein A from ascites

other info2 :

Immunogen: Denatured bacterially expressed recombinant human HLA G heavy chain. Histology Positive Control Tissue: Human placenta - extravillous cytotrophoblast. Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

Mouse anti Human HLA G antibody, clone MEM-G/1 reacts with denatured soluble and membrane-bound HLA G heavy chain. The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In humans, this complex is referred to as the human leukocyte antigen (HLA) region. HLA G belongs to the HLA class I molecules (HLA Class Ib; nonclassical) and is involved in the presentation of foreign antigens to the immune system. This molecule is expressed on the surface of trophoblast cells and plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T lymphocytes, macrophages and mononuclear cells.

ncbi gi num :

4504415

ncbi acc num :

NP_002118.1

ncbi gb acc num :

NM_002127.5

uniprot acc num :

P17693

ncbi mol weight :

38,224 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Allograft Rejection Pathway (920963); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (366163); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (477122); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533)

ncbi summary :

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

uniprot summary :

HLA-G: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells. Belongs to the MHC class I family. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: Golgi membrane; phagocytic vesicle membrane; membrane; early endosome membrane; plasma membrane; MHC class I protein complex. Molecular Function: protein homodimerization activity; peptide antigen binding; receptor binding. Biological Process: immune response-inhibiting cell surface receptor signaling pathway; regulation of immune response; positive regulation of regulatory T cell differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of interleukin-12 production; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; negative regulation of immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of tolerance induction; antigen processing and presentation of peptide antigen via MHC class I; negative regulation of T cell proliferation; cellular defense response; antigen processing and presentation of exogenous peptide antigen via MHC class I; positive regulation of T cell tolerance induction. Disease: Asthma, Susceptibility To

size1 :

0.2 mg

price1 :

530 USD