MOUSE ANTI HUMAN p15 | MyBioSource MBS212441 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI HUMAN p15

catalog :

MBS212441

quantity :

0.1 mg

price :

555 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DCS-114.1

reactivity :

human

application :

western blot, immunoprecipitation

product information

catalog number :

MBS212441

products type :

Antibody

products full name :

MOUSE ANTI HUMAN p15

products short name :

p15

other names :

cyclin-dependent kinase 4 inhibitor B isoform 1; Cyclin-dependent kinase 4 inhibitor B; cyclin-dependent kinase 4 inhibitor B; CDK inhibitory protein; CDK4B inhibitor; MTS-2; cyclin-dependent kinases 4 and 6 binding protein; multiple tumor suppressor 2; p14-INK4b; p14_CDK inhibitor; p14_INK4B; p15 CDK inhibitor; p15-INK4b; p15_INK4B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); Multiple tumor suppressor 2; MTS-2; p14-INK4b; p15-INK4b; p15INK4B

products gene name :

p15

other gene names :

CDKN2B; CDKN2B; P15; MTS2; TP15; CDK4I; INK4B; p15INK4b; MTS2; MTS-2; p15INK4B

uniprot entry name :

CDN2B_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

DCS-114.1

host :

Mouse

sequence length :

138

specificity :

This item recognises human p15ink4b, a 15kD tumour suppressor protein which inhibits the cyclin D dependent kinases cdk4/6

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Frozen, Immunoprecipitation (IP)*, Western Blot (WB)

app notes :

Immunoprecipitation: Application Note: N.B. Clone DCS114.1 co-precipitates cdk4/cdk6.

other info1 :

Perservative Stabilisers: 0.08% Sodium Azide

other info2 :

Immunogen: Full length recombinant p15 His tagged. Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

MBS212441 recognises human p15ink4b, a 15kD tumour suppressor protein which inhibits the cyclin D dependent kinases cdk4/6

ncbi gi num :

17981694

ncbi acc num :

NP_004927.2

ncbi gb acc num :

NM_004936.3

uniprot acc num :

P42772

ncbi mol weight :

8,078 Da

ncbi pathways :

Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Cell Cycle Pathway (83054); Cell Cycle Pathway (463); Cellular Senescence Pathway (905991); Cellular Responses To Stress Pathway (645258); Cyclin D Associated Events In G1 Pathway (105767); Disease Pathway (530764); FoxO Signaling Pathway (921162); G1 Phase Pathway (105766)

ncbi summary :

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

uniprot summary :

p15-INK4B: a potent inhibitor that nteracts strongly with CDK4 and CDK6. Potential effector of TGF-beta induced cell cycle arrest. Protein type: Inhibitor; Protein kinase, regulatory subunit; Cell cycle regulation; Tumor suppressor. Chromosomal Location of Human Ortholog: 9p21. Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus. Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase binding. Biological Process: spleen development; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; megakaryocyte differentiation; mitotic cell cycle checkpoint; positive regulation of transforming growth factor beta receptor signaling pathway; cellular response to nutrient; liver development; response to organic cyclic substance; negative regulation of cell proliferation; response to cytokine stimulus; transforming growth factor beta receptor signaling pathway; cellular response to extracellular stimulus; negative regulation of phosphorylation; positive regulation of epithelial cell differentiation; gene expression; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; cell cycle arrest; G2/M transition of mitotic cell cycle; negative regulation of epithelial cell proliferation; aging

size1 :

0.1 mg

price1 :

555 USD