product summary
request information :
company name :
MyBioSource
product type :
antibody
product name :
RAT ANTI HUMAN EGF RECEPTOR
catalog :
MBS212315
quantity :
0.2 mg
price :
575 USD
clonality :
monoclonal
host :
rat
reactivity :
human
application :
FACS, flow cytometry, immunoprecipitation
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS212315
products type :
Antibody
products full name :
RAT ANTI HUMAN EGF RECEPTOR
products short name :
EGF R
other names :
epidermal growth factor receptor isoform a; Epidermal growth factor receptor; epidermal growth factor receptor; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; erb-b2 receptor tyrosine kinase 1; proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
products gene name :
EGF
other gene names :
EGFR; EGFR; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; ERBB; ERBB1; HER1
uniprot entry name :
EGFR_HUMAN
clonality :
Monoclonal
isotype :
IgG2a
clone :
ICR10
host :
Rat
sequence length :
628
form :
Purified. Purified IgG - liquid
concentration :
IgG concentration 1.0 mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Immunohistology Frozen, Flow cytometry (FC/FACS), Immunoprecipitation (IP), Immunohistology Paraffin
app notes :
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/100
other info1 :
Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by ion exchange chromatography
other info2 :
Immunogen: Extracellular domain of human EGF-receptor from head and neck carcinoma. Histology Positive Control Tissue: Breast Carcinoma. Buffer Solution: Phosphate buffered saline. Target Species: Human
products description :
Rat anti Human EGF Receptor antibody, clone ICR10 recognizes the human epidermal growth factor receptor (EGF-R), which is over expressed in a high proportion of breast cancer cells and in a range of other carcinomas. High level expression of EGFR is often associated with advanced disease and poor prognosis. Rat anti Human EGF Receptor antibody, clone ICR10 binds to epitope B from EGFR (Lottaz et al. 2010 and Modjtahedi et al. 1993) and has an affinity of 6.7 x 10-9 M.
ncbi gi num :
29725609
ncbi acc num :
NP_005219.2
ncbi gb acc num :
NM_005228.3
uniprot acc num :
P00533
ncbi mol weight :
69,228 Da
ncbi pathways :
AGE/RAGE Pathway 698754!!Adaptive Immune System Pathway 366160!!Adherens Junction Pathway 83070!!Adherens Junction Pathway 481!!AhR Pathway 755436!!Alpha6-Beta4 Integrin Signaling Pathway 198807!!Androgen Receptor Signaling Pathway 198806!!Arf6 Signaling Events Pathway 138034!!Axon Guidance Pathway 105688!!Bladder Cancer Pathway 83115
ncbi summary :
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
size :
0.2 mg
price :
575 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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