antibody

MOUSE ANTI HUMAN MUCIN 2

MBS212293

0.2 mg

440 USD

monoclonal

mouse

nonconjugated

996/1

western blot, flow cytometry, FACS

Antibody

MOUSE ANTI HUMAN MUCIN 2

MUCIN 2

mucin-2; Mucin-2; mucin-2; intestinal mucin-2; mucin 2, intestinal/tracheal; mucin-like protein; mucin 2, oligomeric mucus/gel-forming; Intestinal mucin-2

MUCIN 2

MUC2; MUC2; MLP; SMUC; MUC-2; SMUC; MUC-2

MUC2_HUMAN

Monoclonal

IgG1

996/1

Mouse

5,179

Purified. Purified IgG - liquid

IgG concentration 1.0 mg/ml

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

Immunohistology Frozen, Flow cytometry (FC/FACS)*, Immunohistology Paraffin, Western Blot (WB)

Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Flow Cytometry: Application Note: Membrane permeabilization is required for this application. MyBioSource recommend the use of Leucoperm

Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Histology Positive Control Tissue: Normal colon. Buffer Solution: Phosphate buffered saline. Target Species: Human

Mouse anti Human Mucin 2 antibody, clone 996/1 recognizes human Mucin 2 (MUC-2), and shows no cross-reactivity with MUC-1, MUC-3 or MUC-4. In tissue sections Mouse anti Human Mucin 2 antibody, clone 996/1 recognizes colon, liver and prostate tissues strongly. The antibody recognizes malignant colonic mucosa as well as normal mucosa.

557129045

NP_002448.3

NM_002457.3

Q02817

540,300 Da

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Metabolism Of Proteins Pathway (106230); O-linked Glycosylation Pathway (1127679); O-linked Glycosylation Of Mucins Pathway (530747); Post-translational Protein Modification Pathway (161012); Termination Of O-glycan Biosynthesis Pathway (530748); Vibrio Cholerae Infection Pathway (83101); Vibrio Cholerae Infection Pathway (513)

This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

MUC2: Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. Protein type: Secreted; Secreted, signal peptide; Extracellular matrix. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: Golgi lumen. Molecular Function: protein binding. Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; maintenance of gastrointestinal epithelium; post-translational protein modification

0.2 mg

440 USD