catalog number :
MBS212159
products full name :
MOUSE ANTI HUMAN CD119
products short name :
CD119
other names :
interferon gamma receptor 1; Interferon gamma receptor 1; interferon gamma receptor 1; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antiviral protein, type 2; immune interferon receptor 1; interferon-gamma receptor alpha chain; interferon gamma receptor 1; CDw119; CD_antigen: CD119
products gene name :
CD119
other gene names :
IFNGR1; IFNGR1; CD119; IFNGR; IMD27A; IMD27B; IFN-gamma receptor 1; IFN-gamma-R1
uniprot entry name :
INGR1_HUMAN
form :
Purified. Purified IgG - liquid
concentration :
IgG concentration 1.0 mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Immunohistology Frozen*, ELISA (EIA), Flow cytometry (FC/FACS), Western Blot (WB)
app notes :
Flow Cytometry: Use 1ug to label 106 cells in 100ul. Immunohistology - Frozen: Minimum Dilution: 1ug/ml; Maximum Dilution: 10ug/ml; Application Note: The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. MyBioSource recommends the use of acetone fixation for frozen sections. . ELISA: Maximum Dilution: 1ug/ml. Flow Cytometry: Minimum Dilution: 1ug/ml; Maximum Dilution: 10ug/ml. Western Blotting: Maximum Dilution: 1ug/ml
other info1 :
Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by ion exchange chromatography
other info2 :
Immunogen: Fusion protein of the extracellular part of the human interferon-gamma receptor (AA: Ala17-Gly245) to 11 AA of the c-myc proto-oncogene (for affinity purification). Fusion Partners: Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0-Ag14 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Human
products description :
Mouse anti Human CD119 antibody, clone BB1E2 recognizes the human gamma-interferon receptor, also known as CD119. CD119 is expressed by monocytes, and very weakly by resting peripheral blood lymphocytes. Mouse anti Human CD119 antibody, clone BB1E2 has been described as useful for Western Blotting where it stains a single protein band is stained corresponding to a MW of ~43kDa, which is equal to the MW for the glycosylated extracellular domain of the human interferon-gamma receptor (fused to c-myc), and a MW of 27kDa corresponding to the non-glycosylated domain (fused to c-myc). Mouse anti Human CD119 antibody, clone BB1E2 does not neutralize biological activity of interferon gamma.
ncbi acc num :
NP_000407.1
ncbi gb acc num :
NM_000416.2
ncbi mol weight :
21,542 Da
ncbi pathways :
Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Cytokine Signaling In Immune System Pathway 366171!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!HIF-1 Signaling Pathway 695200!!Herpes Simplex Infection Pathway 377873!!Herpes Simplex Infection Pathway 377865!!IFN-gamma Pathway 138040!!Immune System Pathway 106386
ncbi summary :
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]