catalog number :
MBS212032
products full name :
MOUSE ANTI HUMAN IgA SECRETORY CHAIN
products short name :
IgA
other names :
Ig alpha-1 chain C region, partial; Ig alpha-1 chain C region; immunoglobulin heavy constant alpha 1
other gene names :
IGHA1; IGHA1; IgA1
uniprot entry name :
IGHA1_HUMAN
form :
Purified. Purified
concentration :
IgG concentration 1mg/ml
storage stability :
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Immunohistology Frozen, ELISA (EIA), Immunohistology Paraffin
other info1 :
Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein A
other info2 :
Buffer Solution: Tris buffered saline. Target Species: Human
products description :
Mouse anti Human IgA secretory chain antibody, clone Mc29-12 recognizes purified human secretory - chain and secretory IgA. No reaction against myeloma IgA (native or reduced and alkylated). Negative against normal human IgM, myeloma IgM, normal human IgG; free kappa or gamma chains, and J-chain. Typical pattern on frozen and paraffin embedded sections of intestinal and breast tissue.
ncbi mol weight :
37,655 Da
ncbi pathways :
Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Inflammatory Response Pathway (198766); Regulation Of Nuclear SMAD2/3 Signaling Pathway (137963); Scavenging Of Heme From Plasma Pathway (771600)
uniprot summary :
IGHA1: Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system. A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein. Protein type: Immunoglobulin superfamily. Chromosomal Location of Human Ortholog: 14q32.33. Cellular Component: extracellular space; extracellular region. Molecular Function: antigen binding. Biological Process: retinal homeostasis; receptor-mediated endocytosis; glomerular filtration; antibacterial humoral response; immune response; protein-chromophore linkage