MOUSE ANTI HUMAN TENASCIN | MyBioSource MBS211942 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI HUMAN TENASCIN

catalog :

MBS211942

quantity :

0.2 mg

price :

390 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

T2H5

reactivity :

human

application :

western blot, ELISA, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS211942

products type :

Antibody

products full name :

MOUSE ANTI HUMAN TENASCIN

products short name :

TENASCIN

other names :

tenascin; Tenascin; tenascin; GP 150-225; cytotactin; deafness, autosomal dominant 56; glioma-associated-extracellular matrix antigen; hexabrachion (tenascin); myotendinous antigen; neuronectin; tenascin-C additional domain 1; tenascin-C isoform 14/AD1/16; tenascin C; Cytotactin; GMEM; GP 150-225; Glioma-associated-extracellular matrix antigen; Hexabrachion; JI; Myotendinous antigen; Neuronectin; Tenascin-C; TN-C

other gene names :

TNC; TNC; GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225; HXB; TN; TN-C

uniprot entry name :

TENA_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

T2H5

host :

Mouse

sequence length :

2201

specificity :

Clone T2H5 recognizes Tenascin in both normal and hyperproliferative (also neoplastic) tissues. Tenascin has been implicated in the guidance of migrating neurons and axons during development and neuronal regeneration. It promotes cortical neuron outgrowths and is an important component of the wound matrix and scar formation.

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Frozen, ELISA (EIA), Immunoprecipitation (IP), Immunohistology Paraffin*, Western Blot (WB)

app notes :

ELISA: Minimum Dilution: 1/1000; Maximum Dilution: 1/2000;. Immunohistology - Paraffin: Application Note: Staining may be enhanced using trypsin digestion or heat mediated antigen retrieval using sodium citrate buffer pH 6.0.

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant.

other info2 :

Immunogen: Purified protein from human mammary tumour. Histology Positive Control Tissue: Human tonsil. Buffer Solution: TRIS buffered saline . Target Species: Human

products description :

ncbi gi num :

153946395

ncbi acc num :

NP_002151.2

ncbi gb acc num :

NM_002160.3

uniprot acc num :

P24821

ncbi mol weight :

171,360 Da

ncbi pathways :

ECM Proteoglycans Pathway (833812); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Extracellular Matrix Organization Pathway (576262); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); Integrin Cell Surface Interactions Pathway (106110); MicroRNAs In Cancer Pathway (852705); MicroRNAs In Cancer Pathway (852928)

ncbi summary :

This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

uniprot summary :

TNC: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. Belongs to the tenascin family. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 9q33. Cellular Component: extracellular matrix; extracellular space; focal adhesion; membrane; extracellular region; basement membrane. Molecular Function: syndecan binding. Biological Process: osteoblast differentiation; extracellular matrix organization and biogenesis; response to ethanol; wound healing; response to mechanical stimulus; positive regulation of cell proliferation; response to wounding; negative regulation of cell adhesion; cell adhesion; axon regeneration in the peripheral nervous system; neuromuscular junction development; odontogenesis of dentine-containing teeth. Disease: Deafness, Autosomal Dominant 56

size1 :

0.2 mg

price1 :

390 USD

more info or order :

MyBioSource product webpage