antibody

MOUSE ANTI HUMAN SEX HORMONE BINDING GLOBULIN

MBS211920

0.2 mg

580 USD

monoclonal

mouse

nonconjugated

MA026 (1A7)

ELISA, enzyme immunoassay

Antibody

MOUSE ANTI HUMAN SEX HORMONE BINDING GLOBULIN

SEX HORMONE BINDING GLOBULIN

sex hormone-binding globulin isoform 1; Sex hormone-binding globulin; sex hormone-binding globulin; sex steroid-binding protein; testis-specific androgen-binding protein; testosterone-binding beta-globulin; testosterone-estradiol-binding globulin; testosterone-estrogen-binding globulin; sex hormone-binding globulin; Sex steroid-binding protein; SBP; Testis-specific androgen-binding protein; ABP; Testosterone-estradiol-binding globulin; TeBG; Testosterone-estrogen-binding globulin

SHBG; SHBG; ABP; SBP; TEBG; SHBG; SBP; ABP; TeBG

SHBG_HUMAN

Monoclonal

IgG2a

MA026 (1A7)

Mouse

402

Purified. Ig fraction - liquid

Approximate Protein Concentration: 0.5 mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

ELISA (EIA)

Immunogen: Purified SHBG from human serum. Perservative Stabilizers: 0.09% Sodium Azide (NaN3). Preparation: Ig fraction prepared by caprylic acid fractionation

Buffer Solution: Phosphate buffered saline. Affinity: 2.1 x 10 9 M -1 . Target Species: Human

Mouse anti human sex hormone binding globulin antibody, clone MA026 (1A7) recognizes sex hormone binding globulin (SHBG), a 45 kDa plasma glycoprotein dimer. SHBG is an androgen transport protein which binds and regulates the free concentration of steroid hormones and is involved in steroid signalling at the cell membrane. This antibody shows minimal cross-reactivity with other human serum proteins.

7382460

NP_001031.2

NM_001040.4

P04278

41,712 Da

Nongenotropic Androgen Signaling Pathway (138048)

This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

SHBG: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: extracellular region. Molecular Function: androgen binding. Biological Process: primary spermatocyte growth

0.2 mg

580 USD