antibody

MOUSE ANTI HUMAN PROSTATE SPECIFIC ANTIGEN

MBS211883

1 mg

340 USD

monoclonal

mouse

nonconjugated

214

ELISA, enzyme immunoassay

Antibody

MOUSE ANTI HUMAN PROSTATE SPECIFIC ANTIGEN

PROSTATE SPECIFIC ANTIGEN

prostate-specific antigen isoform 3 preproprotein; Prostate-specific antigen; prostate-specific antigen; P-30 antigen; gamma-seminoprotein; kallikrein-3; prostate specific antigen; semenogelase; seminin; kallikrein-related peptidase 3; Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase

KLK3; KLK3; APS; PSA; hK3; KLK2A1; APS; PSA; Seminin

KLK3_HUMAN

Monoclonal

IgG1

214

Mouse

238

Prostate specific antigen

Purified. Purified IgG - liquid

IgG concentration 1.0 mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

ELISA (EIA)

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein A.

Immunogen: Highly pure Prostate Specific Antigen from human prostate. Buffer Solution: Phosphate buffered saline. Target Species: Human

Mouse anti Human Prostate Specific Antigen antibody, clone 214 recognizes Prostate Specific Antigen (PSA), recognising both the free and complexed forms.

71834853

NP_001025218.1

NM_001030047.1

P07288

25,116 Da

Androgen Receptor Signaling Pathway (198806); Coregulation Of Androgen Receptor Activity Pathway (138085); FOXA1 Transcription Factor Network Pathway (137979); Metabolism Of Proteins Pathway (106230); Pathways In Cancer (83105); Prostate Cancer Pathway (755440); Prostate Cancer Pathway (83111); Prostate Cancer Pathway (523); Regulation Of Androgen Receptor Activity Pathway (138027); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908)

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

PSA: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Forms heterodimer with SERPINA5. Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Belongs to the peptidase S1 family. Kallikrein subfamily. Protein type: Secreted, signal peptide; Protease; Secreted; EC 3.4.21.77. Chromosomal Location of Human Ortholog: 19q13.41. Cellular Component: extracellular region; nucleus. Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity. Biological Process: negative regulation of angiogenesis; cellular protein metabolic process; proteolysis

1 mg

340 USD