MOUSE ANTI HUMAN PARATHYROID HORMONE | MyBioSource MBS211855 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI HUMAN PARATHYROID HORMONE

catalog :

MBS211855

quantity :

0.2 mg

price :

265 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

BGN/1F8

reactivity :

human, mouse, rat

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS211855

products type :

Antibody

products full name :

MOUSE ANTI HUMAN PARATHYROID HORMONE

products short name :

PARATHYROID HORMONE

other names :

parathyroid hormone preproprotein; Parathyroid hormone; parathyroid hormone; parathormone; parathyrin; parathyroid hormone 1; prepro-PTH; preproparathyroid hormone; parathyroid hormone; Parathormone; Parathyrin

other gene names :

PTH; PTH; PTH1; PTH

uniprot entry name :

PTHY_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

BGN/1F8

host :

Mouse

reactivity :

Mouse, Rat

sequence length :

115

form :

Purified. Purified IgG - liquid

concentration :

Approximate Protein Concentration: 1.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Frozen, ELISA (EIA), Immunohistology Paraffin

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein A

other info2 :

Buffer Solution: Phosphate buffered saline. Affinity: 2 x 107with 1-34 PTH5 x 108 with 1-84 PTH. Target Species: Human

products description :

Mouse anti Human parathyroid hormone monoclonal antibody, clone BGN/1F8 recognizes human parathyroid hormone (PTH) also known as Parathyrin. PTH is a hormone produced by the parathyroid gland resposible for the regulation of calcium and phosphorus concentrations in extracellular fluid (Brown 1983). It is produced in the parathyroid gland as a 115 amino acid single chain polypeptide, bearing a 25 amino acid signal peptide, a 6amino acid propeptide sequence and an 84amino acid mature hormone. (Keutmann et al. 1978). Defects in this gene are a cause of familial isolated hypoparathyroidism (Arnold et al. 1990).

ncbi gi num :

4506267

ncbi acc num :

NP_000306.1

ncbi gb acc num :

NM_000315.2

uniprot acc num :

P01270

ncbi mol weight :

12,861 Da

ncbi pathways :

Class B/2 (Secretin Family Receptors) Pathway (106378); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); Endochondral Ossification Pathway (198812); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Metabolic Disorders Of Biological Oxidation Enzymes Pathway (1127637); Osteoblast Signaling Pathway (198842); Signal Transduction Pathway (477114)

ncbi summary :

The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). [provided by RefSeq, Jul 2008]

uniprot summary :

PTH: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism. Belongs to the parathyroid hormone family. Protein type: Secreted, signal peptide; Hormone; Secreted; Apoptosis. Chromosomal Location of Human Ortholog: 11p15.3-p15.1. Cellular Component: extracellular space; extracellular region. Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; type 1 parathyroid hormone receptor binding; peptide hormone receptor binding; parathyroid hormone receptor binding; hormone activity. Biological Process: response to drug; transcription from RNA polymerase II promoter; positive regulation of signal transduction; induction of apoptosis by hormones; positive regulation of glycogen biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of bone mineralization; G-protein signaling, adenylate cyclase activating pathway; Rho protein signal transduction; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; positive regulation of glucose import; response to ethanol; response to cadmium ion; response to vitamin D; cAMP metabolic process; cell-cell signaling; regulation of gene expression; response to lead ion; positive regulation of cAMP biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; skeletal development; bone resorption. Disease: Hypoparathyroidism, Familial Isolated

size1 :

0.2 mg

price1 :

265 USD

more info or order :

MyBioSource product webpage