MOUSE ANTI HUMAN CYTOKERATIN 19 | MyBioSource MBS211749 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI HUMAN CYTOKERATIN 19

catalog :

MBS211749

quantity :

0.2 mg

price :

390 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

A53-B/A2

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS211749

products type :

Antibody

products full name :

MOUSE ANTI HUMAN CYTOKERATIN 19

products short name :

CYTOKERATIN 19

other names :

keratin, type I cytoskeletal 19; Keratin, type I cytoskeletal 19; keratin, type I cytoskeletal 19; 40-kDa keratin intermediate filament; CK-19; cytokeratin 19; cytokeratin-19; keratin, type I, 40-kd; keratin 19, type I; Cytokeratin-19; CK-19; Keratin-19; K19

other gene names :

KRT19; KRT19; K19; CK19; K1CS; CK-19; K19

uniprot entry name :

K1C19_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

clone :

A53-B/A2

host :

Mouse

sequence length :

400

form :

Purified. Purified IgG - liquid

concentration :

Approximate Protein Concentration: 1.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Shelf Life: 18 months from date of despatch.

tested application :

ELISA (EIA), Immunofluorescence (IF), Immunohistology Paraffin*, Western Blot (WB)

app notes :

Western Blot: In Western blotting 40 kD and 19 kD bands are observed. Immunohistology - Paraffin: Minimum Dilution: 1/100; Maximum Dilution: 1/200; Application Note: This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase.

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

other info2 :

Histology Positive Control Tissue: Appendix. Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

Mouse anti Human cytokeratin 19 antibody, clone A53-B/A2 recognizes the rod domain (aa 312-335) of human cytokeratin 19 (B ttger; et al. 1995) also known as keratin 19 encoded by the KRT19 gene. Cytokeratin 19 is a 400 amino acid intermediate filament protein lacking a C-terminal tail domain, in contrast to all other intermediate filament proteins. Cytokeratin 19 expression is observed in striated muscle where it is involved in forming the association between the contractile apparatus and dystrophin (Stone et al. 2005). Expression is also seen in many ductal and glandular cells together with a restricted set of normal and neoplasic epithelial cells. Mouse anti Human cytokeratin 19 antibody, clone A53-B/A2 detects a band of ~45 kDA in Western blotting using an A-549 human alveolar adenocarcinoma cell line lysate.

ncbi gi num :

24234699

ncbi acc num :

NP_002267.2

ncbi gb acc num :

NM_002276.4

uniprot acc num :

P08727

ncbi mol weight :

44,106 Da

ncbi pathways :

Signaling Mediated By P38-alpha And P38-beta Pathway (138012)

ncbi summary :

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

uniprot summary :

K19: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 19 differs from all other IF proteins in lacking the C-terminal tail domain. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 17q21.2. Cellular Component: dystrophin-associated glycoprotein complex; costamere; intermediate filament; Z disc; sarcolemma. Molecular Function: protein binding; structural constituent of cytoskeleton; structural constituent of muscle; protein complex binding. Biological Process: viral reproduction; response to estrogen stimulus; sarcomere organization

size1 :

0.2 mg

price1 :

390 USD

more info or order :

MyBioSource product webpage