MOUSE ANTI HUMAN FIBRONECTIN (MATRIX) | MyBioSource MBS211644 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI HUMAN FIBRONECTIN (MATRIX)

catalog :

MBS211644

quantity :

0.2 mg

price :

235 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

EP5

reactivity :

human, mouse

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS211644

products type :

Antibody

products full name :

MOUSE ANTI HUMAN FIBRONECTIN (MATRIX)

products short name :

FIBRONECTIN

other names :

fibronectin isoform 3 preproprotein; Fibronectin; fibronectin; cold-insoluble globulin; migration-stimulating factor; fibronectin 1; Cold-insoluble globulin; CIG

other gene names :

FN1; FN1; FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2; FN; FN; CIG

uniprot entry name :

FINC_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

EP5

host :

Mouse

reactivity :

Mouse

sequence length :

2355

specificity :

Recognises fibronectin in human and mouse tissues, specifically connective tissues and vessels. No reactivity with the soluble dimeric form of fibronectin (plasma fibronectin), but highly reactive with matrix fibronectin.

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Frozen, Immunohistology Paraffin*

app notes :

Immunohistology - Paraffin: Minimum Dilution: 1/25; Maximum Dilution: 1/100; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3). Preparation: Purified IgG prepared by affinity chromatography on Protein A

other info2 :

Immunogen: Native human fibronectin (matrix). Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

ncbi gi num :

16933542

ncbi acc num :

NP_002017.1

ncbi gb acc num :

NM_002026.2

uniprot acc num :

P02751

ncbi mol weight :

256,502 Da

ncbi pathways :

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Bacterial Invasion Of Epithelial Cells Pathway (149807); Bacterial Invasion Of Epithelial Cells Pathway (148661); Cell Surface Interactions At The Vascular Wall Pathway (106062); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Extracellular Matrix Organization Pathway (576262); Fibronectin Matrix Formation Pathway (771601)

ncbi summary :

This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

uniprot summary :

FN1: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2); also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. 15 isoforms of the human protein are produced by alternative splicing. Protein type: Cell adhesion; Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 2q34. Cellular Component: extracellular matrix; extracellular space; apical plasma membrane; fibrinogen complex; ER-Golgi intermediate compartment; extracellular region; basal lamina. Molecular Function: collagen binding; heparin binding; integrin binding; protein binding; protease activator activity; protease binding. Biological Process: integrin activation; platelet activation; extracellular matrix organization and biogenesis; positive regulation of axon extension; extracellular matrix disassembly; regulation of cell shape; platelet degranulation; cell-substrate junction assembly; calcium-independent cell-matrix adhesion; acute-phase response; response to wounding; peptide cross-linking; angiogenesis; blood coagulation; cell adhesion; leukocyte migration. Disease: Glomerulopathy With Fibronectin Deposits 2; Plasma Fibronectin Deficiency

size1 :

0.2 mg

price1 :

235 USD

more info or order :

MyBioSource product webpage